Overview

This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively.   Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters.      This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein.   The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

Full Product Details

Author:   Julio A. Aguirre-Ghiso
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2018
Volume:   1100
Weight:   0.689kg
ISBN:  

9783319977454

ISBN 10:   3319977458
Pages:   162
Publication Date:   22 November 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface.- Foreword. Understanding and targeting minimal residual disease: a path to change cancer patient outcomes.- Epigenetics and Pluripotency Aspects of Disseminated Cancer Cells during Minimal Residual Disease.- Anti-angiogenic therapy-mediated endothelial damage: A driver of breast cancer recurrence?- Minimal Residual Disease in Prostate Cancer.- Minimal Residual Disease in Head and Neck Cancer and Esophageal Cancer.- Detection of Minimal Residual Disease and its Clinical Applications in Melanoma and Breast Cancer Patients Selena.- Preservation of Quiescent Chronic Myelogenous Leukemia Stem Cells by the Bone Marrow Microenvironment.-Minimal Residual Disease in Acute Myeloid leukemia.- Characteristics and therapeutic targeting of minimal residual disease in childhood acute lymphoblastic leukemia.- Minimal Residual Disease in Multiple Myeloma: Impact on response assessment, prognosis and tumor heterogeneity.- Index.  

Reviews

Professor Aguirre-ghiso's research has frequently made cover of several high impact factor journals - Nature Cell Biology, Nature Reviews Cancer, Cancer Cell, MCB. His complete list of publications - http: //www.ncbi.nlm.nih.gov/pubmed/?term=aguirre-ghiso has over 10,000 citations in Google Scholar. Harper KL, Sosa MS, Entenberg D, Hosseini H, Cheung JF, Nobre R, Avivar-Valderas A, Nagi C, Girnius N, Davis RJ, Farias EF, Condeelis J, Klein CA, Aguirre-Ghiso JA. Mechanism of early dissemination and metastasis in HER2+ mammary cancer. Nature. (2016) Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] PMID:27974798. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted by Faculty of 1000. https: //f1000.com/prime/727099751; Highlighted in Nature Reviews Cancer http: //www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.htm Hosseini, H, Obradovic M, Harper K, Sosa MS, Nanduri LK, Werno C, Hoffman, M, Ehrl C, Maneck M, Patwary N, Haunschild G, Reimelt C, Weeber F, Hartkopf A, Taran FA, Brucker SY, Fehm T, Meister G, Aguirre-Ghiso JA, Klein CA. Early dissemination seeds metastasis in breast cancer. Nature. (2016) Dec 14. doi: 10.1038/nature20785. [Epub ahead of print] PMID:27974799. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted in Nature Reviews Cancer http: //www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html Aguirre-Ghiso Lab work Highlighted in different news media. YouTube: https: //www.youtube.com/watch?v=v7khjJPYZro https: //www.youtube.com/watch?v=vdZ-vcC9FkY&list=PLqLDR0CTP9_qPNn3QeIGeavdiYP0djhqD https: //www.youtube.com/watch?v=XF6hJlFhpOo Other media outlets: - 5/5/2017 - The Aguirre-Ghiso lab receives a new grant! Check out the press release. Researchers receive $2.9 million grant for breast cancer metastasis study - http: //bit.ly/2q0N8MS - 5/4/17 Co-chair of the1st @AACR meeting on Cancer Dormancy & Residual Disease; with Dorothy Sipkins Cyrus Ghajar & Christoph Klein. http: //www.aacr.org/Meetings/Pages/MeetingDetail.aspxEventItemID=138&DetailItemID=665#.WQpGlVLlRhH https: //nature.altmetric.com/details/15709422/news https: //nature.altmetric.com/details/14748848/news https: //nature.altmetric.com/details/14748850/news http: //www.labmanager.com/news/2016/12/how-cancer-can-spread-even-before-a-tumor-develops?fw1pk=2 http: //www.genengnews.com/gen-news-highlights/cancer-branches-early-bears-metastatic-fruit-later/81253564 http: //www.businessinsider.com/new-cancer-study-cells-spread-earlier-than-thought-2016-12 https: //www.eurekalert.org/pub_releases/2016-12/msh-rrh121216.php http: //www.invdes.com.mx/salud/4594-descubren-mecanismo-de-metastasis-temprana-en-cancer-de-mama.html https: //www.sciencedaily.com/releases/2015/01/150131131103.htm http: //www.news-medical.net/news/20150131/NR2F1-gene-A-master-regulator-of-tumor-cell-growth.aspx https: //www.sciencedaily.com/releases/2013/10/131027185200.htm http: //www.medicalnewstoday.com/releases/268005.php http: //www.news-medical.net/news/20131028/Study-confirms-the-seed-and-soil-theory-of-metastasis.aspx https: //www.eurekalert.org/pub_releases/2013-10/tmsh-msr102313.php

Author Information

Professor Dr. Julio Aguirre-Ghiso is the Director of Head and Neck Cancer Basis Research and Solid Tumor and Metastasis Research. His research group is part of the Division of Hematology and Oncology, Department of Medicine in Mount Sinai. Professor Aguirre-Ghiso has made outstanding contributions in unraveling the Biology of Residual Disease. 

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