Overview

This book aims to engage the Young Science—Talented and Ambitious, for a lasting collaboration in holistic mathematical modeling of “how the body works”under permanent impact from variant life-sphere surroundings. It is then a road-map for challenging research in all aspects of human biology and health.   Following up on its predecessor, BIOKYBERNETIKA (2024), this book “grounds” an axiomatic functional physiology in biology, and elaborates on the roles of thermo¬dynamic entropy in evolution, of allostatic load at the verge of health and disease, and of environmental and social factors in senescence and frailty.  For cellular systems, enzyme structures, virus infection progression, and tumor growth in vitro are modeled, while dynamics in physiology address vascular transports with liver detoxification interaction, and cortisol rhythmicity. Epidemiological virus spread and self-organization in urban eco-systems touch on population dynamics.   AI applications focus on medical data bases and on video supervision of sperm injection; direct therapeutical impact have systems endocrinology in precision medicine and optimization in adaptive cancer therapy.  Interested are systems-oriented researchers in all sciences related to human health. 

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9783119144803

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1. Jochen Mau is professor (em) of Biomathematics and Statistics in Medicine, Heinrich Heine University Düsseldorf, Germany. He holds a dr.rer.nat. degree in mathematics from University of Mainz, and dr. habil. degree in medical biometry from University of Tübingen, Germany. He had contributed to statistical theory of bioequivalence in industry,  of counting processes for multi-state chronic disease, engaged in clinical studies on dental implants, and multi-national trials of acute ischemic stroke. As founder of “Initiative Biokybernetik”, he calls to advance multi-scale modeling of human-body system from an engineering perspective. He is corresponding editor of BIOKYBERNETIKA (2024). He works on a theoretical physiology based on axiomatic functional biodynamics.  2. Sergey Mukhin, Doctor of Physical and Mathematical Sciences since 2009, is professor and Deputy Head of Department of Computational Methods, Faculty of Computational Mathematics and Cybernetics, Lomonosov Moscow State University. As author of more than 100 scientific papers in the area of numerical methods and mathematical modeling, his recent focus is on mathematical modeling of the human circulatory system and related tasks. He is member of the Editorial Board of the Journal ""Bulletin of Moscow University: Computational Mathematics and Cybernetics"", reviewer for Journals ""Mathematical Modeling"" and ""Differential Equations"". 3. Guanyu Wang is associate professor of The Chinese University of Hong Kong, Shenzhen, School of Medicine, permanent council member of “Computational Systems Biology Branch” of Chinese Operations Research Society, member of “Molecular Systems Biology Specialized Committee” of Chinese Society of Biochemistry and Molecular Biology. He was research assistant professor of University of Texas Health Science Center at Houston, and of George Washington University Physics Department, and associate professor of Southern University of Science and Technology.  Prof. Wang published as first or corresponding author more than 60 papers in SCI journals such as PRL, PNAS, JBC,  J Roy Soc Interface, iScience, IEEE Transactions, Trends Immunol,  Sci Bull, Theranostics, He also published a monograph “Analysis of Complex Diseases: A Mathematical Perspective” (CRC Press).    4. Shuhua Xu is a professor of human population genetics and a Distinguished Professor of Fudan University. He is the Director of Center of Evolutionary Biology, and President of the Council, Shanghai Society of Genetics. The Population Omics Group led by Dr. Xu is using computational approaches and developing new methods to dissect the genetic architecture of human populations, quantitatively characterize their admixture features, and reveal their migration history and adaptive divergence. Dr. Xu has authored many scientific papers published in Nature, Science, Cell, PNAS. Dr. Xu serves as an Editorial Board member of several international peer-reviewed journals such as Molecular Genetics and Genomics (co-Editor-in-Chief), BMC Genetics (Section Editor), BMC Genomic Data (Senior Editor).  5. Željko Čupić, PhD, is Principal Research Fellow and President of the Scientific Council at the University of Belgrade - Institute of Chemistry, Technology and Metallurgy - National Institute of the Republic of Serbia, as well as Secretary of the Society of Physical Chemists of Serbia, General Secretary of Serbian Academy of Nonlinear Sciences, and Secretary of Department for Natural and Mathematical Sciences at the Scientific Society of Serbia. His research includes phenomenology and theory of self-organization of nonlinear, non-equilibrium systems and their dynamics. Mostly, he published on numerical modeling of homogeneous oscillators (Bray-Liebhafsky, Belousov-Zhabotinsky, Orban-Epstine) and biological oscillators in the hypothalamic-pituitary-adrenal system.

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