Overview

Bioinorganic Chemistry: Cellular Systems and Synthetic Models includes chapters describing cutting-edge work by renowned researchers in the field that fall within two main areas of current bioinorganic chemistry: (1) the study of cellular systems and processes that occur inside cells that are impacted by inorganic elements, e.g., biosynthetic pathways leading to the production of vital metal-containing enzymes and proteins including iron-sulfur clusters, hemes, and cytochrome c oxidase; metal homeostasis (Zn2+ in E. coli); and new strategies to examine DNA targeting by metal-based drugs using, as an example, the clinically-employed bleomycin class of antitumor agents, and (2) sophisticated new inorganic model systems, many of which escape the traditional approach of trying to use structural mimics of the native systems to produce functional mimics and instead use a more conceptual approach to the use of bioinorganic models to understand the native system or to develop useful synthetic molecules. In the former area, unlike most traditional efforts in bioinorganic chemistry that have been devoted to studies of the structures and functions of metal centers located within individual metal-containing proteins, the topics described in this volume seek to describe whole systems of interaction between multiple interacting biomolecules that are impacted by inorganic species. In the latter area, along with chapters devoted to more traditional ligand systems and inorganic reactivities, peptide- and protein-like ligand systems are emphasized creating agents that: lead to novel structures and morphologies, de novo designed systems that model biological Hg binding, and unique DNA-targeted agents that mimic the activities of nucleic acid-targeted natural products and proteins. Together, these chapters provide examples of the exciting current work in two important areas in the exciting field of bioinorganic chemistry.

Full Product Details

Author:   Eric C. Long (Indiana Univerisity-Purdue University Indianapolis (IUPUI)) ,  Michael J. Baldwin (University of Cincinnati)
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Volume:   1012
Dimensions:   Width: 16.00cm , Height: 1.90cm , Length: 23.80cm
Weight:   0.478kg
ISBN:  

9780841269750

ISBN 10:   0841269750
Pages:   264
Publication Date:   16 October 2010
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   No Longer Our Product
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

PrefaceEric C. Long and Michael J. Baldwin: Part I - Cellular Systems 1: J. A. Cowan: Iron Sulfur Cluster Biosynthesis: Scaffold and Donor Proteins, and Mechanistic Insights 2: Kalyan C. Kondapalli, Andrew Dancis and Timothy L. Stemmler: Molecular Interaction Between Frataxin and Ferrochelatase During Heme Assembly: Frataxin's Role as a Potential Iron Chaperone During Heme Biosynthesis 3: Eric L. Hegg: Biosynthesis and Regulation of the Heme: A Biosynthetic Pathway 4: Zhihong Wang and Eric L. Hegg: Assembly of Cytochrome c Oxidase 5: Eric C. Long, Millie M. Georgiadis, Kristie D. Goodwin and Mark A. Lewis: New Approaches to Analyzing the Site Selectivities and Crystal Structures of DNA Targeted Metal Complexes 6: Thusitha Gunasekera, J. Allen Easton, Stacy A. Sugarbaker, Lindsey Klingbeil and Michael W. Crowder: Zn(II) Homeostasis in E. coli Part II - Synthetic Models 7: Martin G. O'Toole and Craig A. Grapperhaus: N2S3X-Fe Models of Nitrile Hydratase 8: Christopher Ziegler: Studies Into the Metal Chemistry of the Carbaporphyrinoids: Insights Into the Biological Choice of Porphyrin 9: Micheal J. Baldwin, Jeanette A. Krause, Michael J. Goldcamp, Michael Haven, Sara E. Edison and Leah N. Squires: Bioinspired Aerobic Substrate Oxidation: A Ni(II)-Oximate Catalyst that Parallels Biological Alcohol and Amine Oxidation Chemistry 10: Franklin A. Schultz, Richard L. Lord, Xiaofan Yang and Mu-Hyun Baik: Inorganic Models for Two-Electron Redox Chemistry in Biological Systems: Ligand-Bridged Molybdenum and Tungsten Dimers 11: Jing Hong, Olesya A. Kharenko, Mikhail V. Tsurkan and Michael Y. Ogawa: Metal-Mediated Peptide Assembly: From Discrete Molecular Species to Large-Scale Morphologies 12: Vincent L. Pecoraro, Anna F. A. Peacock, Olga Iranzo and Marek Luczkowski: Understanding the Biological Chemistry of Mercury Using a de novo Protein Design Strategy 13: Brian W. Kail, Charles G. Young, Mitchell E. Johnson and Partha Basu: Understanding Oxotransferase Reactivity in a Model System Using Singular Value Decomposition Analysis 14: Eric C. Long, Ya-Yin Fang and Mark A. Lewis: DNA Minor Groove Recognition by Ni(II)- and Cu(II)-Gly-Gly-His Derived Metallopeptides

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Author Information

Eric C. Long is Professor of Chemistry at Indiana University - Purdue University Indianapolis (IUPUI). Michael J. Baldwin is Associate Professor at the University of Cincinnati.

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