Overview

Bioinformatics and Drug Discovery describes the bioinformatic approaches and techniques employed along the pipeline of drug development from genes to proteins to drugs. The book focuses on gene microarray analysis and techniques for target identification and validation. In addition, clinical applications showing how the analysis can be used for prognostication and diagnosis are described. The second section focuses on protein analysis, including target validation and identification using modern proteomic analysis as well as protein modeling techniques. The third section discusses chemoinformatics, including virtual screening and how to computationally approach chemical space.

Full Product Details

Author:   Richard S. Larson
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2006 ed.
Volume:   316
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   0.840kg
ISBN:  

9781588293466

ISBN 10:   1588293467
Pages:   444
Publication Date:   01 October 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

New Strategies in Drug Discovery.- Basic Microarray Analysis.- From Microarray to Biological Networks.- Microarray Analysis in Drug Discovery and Clinical Applications.- Ontology-Driven Approaches to Analyzing Data in Functional Genomics.- Gene Evolution and Drug Discovery.- Standardization of Microarray and Pharmacogenomics Data.- Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics.- Protein Interactions Probed With Mass Spectrometry.- Discovering New Drug-Targeting Sites on Flexible Multidomain Protein Kinases.- Nuclear Magnetic Resonance-Based Screening Methods for Drug Discovery.- Receptor-Binding Sites.- In Silico Protein Design.- Chemical Database Preparation for Compound Acquisition or Virtual Screening.- Bioinformatics Platform Development.

Reviews

...succeeds admirably in illuminating the latest interdisciplinary techniques being applied to drug discovery, including target selection and validation, receptor binding site characterization and binding prediction, and use for new lead discovery. - Journal of Medicinal Chemistry

.,. succeeds admirably in illuminating the latest interdisciplinary techniques being applied to drug discovery, including target selection and validation, receptor binding site characterization and binding prediction, and use for new lead discovery. - Journal of Medicinal Chemistry

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