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Author:   W. Wohlleben ,  T. Spellig ,  B. Müller-Tiemann
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2005 ed.
Volume:   51
Dimensions:   Width: 14.90cm , Height: 2.30cm , Length: 21.10cm
Weight:   0.607kg
ISBN:  

9783540220923

ISBN 10:   3540220925
Pages:   284
Publication Date:   29 November 2004
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design.- Sources of Polyketides and Non-Ribosomal Peptides.- Polyketide Synthases: Mechanisms and Models.- Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptlde Synthetases.- Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters.- Engineering Glycosylation in Bioactive Compounds by Combinatorial Biosynthesis.- Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds.- Enzymatic Incorporation of Halogen Atoms into Natural Compounds.- From Glucose to Antibiotics: What Controls the Fluxes?.- Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides.- Tool-Box: Tailoring Enzymes for Bio-Combinatorial Lead Development and as Markers for Genome-Based Natural Product Lead Discovery.- Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming.

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