Overview

Sugars that decorate the surfaces of proteins and cells represent a unique form of information that is used in communication both within and between cells. The science of glycobiology examines the roles of these glycans in protein trafficking, cell-cell adhesion, organization of the extracellular matrix, signalling and other processes. Because sugars are not encoded directly in genomes, the enzymes that assemble complex oligosaccharides, and the lectins that recognize them, provide essential links between genomes and glycobiology. The availability of complete genome sequences provides an opportunity to take a global view of the field. This text focuses on what can be learned about the biological functions of glycans from the genomic analysis of lectins and biosynthetic enzymes. It explores special tactics that are needed to develop an overview of the glycans that are present in an organism and highlights both the advantages and limitations of working with simpler model organisms. The book illustrates not only what can be learned, but also provides speculation on how the field of glycobiology will develop in the future.

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9781855781542

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