Overview

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world.  Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

Full Product Details

Author:   Karuppusamy Arunachalam ,  Sreeja Puthanpura Sasidharan
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1st ed. 2021
Weight:   0.544kg
ISBN:  

9781071612354

ISBN 10:   1071612352
Pages:   271
Publication Date:   17 February 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Overview.- Cell Culture Assays.- Phytochemical Analysis.- Preclinical Drug Dose Calculation.- Toxicology Studies (In Vitro and In Vivo).- Standard Procedure for Anesthesia in Preclinical Experiments.- General Considerations and Collection of Animal Blood.- Animal Experiments on the Cardiovascular System.- Animal Experiments on Ulcerative Colitis.- Experiments on Anti-Bacterial Activities.- Experiments on Anti-Fungal Activities.- Animal Experiment on Wound Healing Activity.- Animal Experiments of Anti-inflammatory Activities.- Animal Experiment on Anti-Nociceptive Activities.- Experiments on Anti-Oxidant Activities.- Animal Experiments on Hepatoprotective Activities.- Animal Experiments on Anti-Diarrheal Activities.- Animal Experiments on Central Nervous System (CNS).- Experiments on Anti-Cancer Activities (In Vitro and In Vivo).- Animal Experiments on Anti-Diabetic Activities.- Animal Experiments on Gastric Ulcer.- Protein Extraction and Western Blot Analysis.- Gel Electrophoresis and PCR Amplification.- Molecular Docking Methods for Drug Design.

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