Overview

This volume contains the proceedings from the Phytochemical Society of Europe's symposium on this topic, held August 24-27, 1997, in Uppsala, Sweden. In it, leading academic and industrial scientists discuss methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumour, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented. The volume seeks to bridge the gap between academic and industrial research, and should be useful reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Full Product Details

Author:   Lars Bohlin ,  Jan G. Bruhn
Publisher:   Springer
Imprint:   Springer
Edition:   1999 ed.
Volume:   43
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   0.484kg
ISBN:  

9780792354802

ISBN 10:   079235480
Pages:   203
Publication Date:   31 January 1999
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Plant Biodiversity — Evolutionary and Ecological Perspectives.- Chemodiversity and the Biological Role of Secondary Metabolites, Some Thoughts for Selecting Plant Material for Drug Development.- Evolving Strategies for the Selection, Dereplication and Prioritization of Antitumor and HIV-Inhibitory Natural Products Extracts.- Screening Methods for Detection and Evaluation of Biological Activities of Plant Preparations.- The Use of Receptor Binding, a Very Specific, High Capacity Screening Method, in the Identification of Biologically Active Components from Natural Sources.- Biological and Chemical Evaluation of Plant Extracts and Subsequent Isolation Strategy.- Natural Products with Antiprotozoal Activity.- In-Vitro Assays for Activity-Guided Enrichment of Immunomodulatory Plant Constituents.- Search for Potent Immunomodulatory Agents from Plants and Other Sources.- Cyclooxygenase and 5-Lipoxygenase as Targets for Medicinal Plant Research.- Natural Products in Drug Discovery and Development.- QPRI’s System for Screening of Natural Products.- Phytera’s Strategy for the Discovery of Novel Anti-Infective Agents from Plant Cell Cultures.- Expediting Drug Development Through the Use of Plants.- The Future Role of Natural Products in Drug Discovery.

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