Overview

Big Data in Omics and Imaging: Association Analysis addresses the recent development of association analysis and machine learning for both population and family genomic data in sequencing era. It is unique in that it presents both hypothesis testing and a data mining approach to holistically dissecting the genetic structure of complex traits and to designing efficient strategies for precision medicine. The general frameworks for association analysis and machine learning, developed in the text, can be applied to genomic, epigenomic and imaging data. FEATURES Bridges the gap between the traditional statistical methods and computational tools for small genetic and epigenetic data analysis and the modern advanced statistical methods for big data Provides tools for high dimensional data reduction Discusses searching algorithms for model and variable selection including randomization algorithms, Proximal methods and matrix subset selection Provides real-world examples and case studies Will have an accompanying website with R code The book is designed for graduate students and researchers in genomics, bioinformatics, and data science. It represents the paradigm shift of genetic studies of complex diseases– from shallow to deep genomic analysis, from low-dimensional to high dimensional, multivariate to functional data analysis with next-generation sequencing (NGS) data, and from homogeneous populations to heterogeneous population and pedigree data analysis. Topics covered are: advanced matrix theory, convex optimization algorithms, generalized low rank models, functional data analysis techniques, deep learning principle and machine learning methods for modern association, interaction, pathway and network analysis of rare and common variants, biomarker identification, disease risk and drug response prediction.

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9781032095981

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Reviews

This is a fantastic book intensively focusing on the mathematical underpinnings of modern genome-wide association studies (GWAS). It serves well for senior graduate students in applied mathematics, computer science, and statistics who are interested in building a solid mathematical understanding of GWAS. Backgrounds of advanced mathematics and genetics are expected. It can also be used as a handbook for professionals to quickly check mathematical contexts of GWAS approaches and tools. This book is especially helpful for the latest generation of statistical geneticists who are pursuing academic career paths. ~Journal of the American Statistical Association, Jing Su (Wake Forest School of Medicine)

"""This is a fantastic book intensively focusing on the mathematical underpinnings of modern genome-wide association studies (GWAS). It serves well for senior graduate students in applied mathematics, computer science, and statistics who are interested in building a solid mathematical understanding of GWAS. Backgrounds of advanced mathematics and genetics are expected. It can also be used as a handbook for professionals to quickly check mathematical contexts of GWAS approaches and tools. This book is especially helpful for the latest generation of statistical geneticists who are pursuing academic career paths."" ~Journal of the American Statistical Association, Jing Su (Wake Forest School of Medicine)"

Author Information

Momiao Xiong, is a professor in the Department of Biostatistics, University of Texas School of Public Health, and a regular member in the Genetics & Epigenetics (G&E) Graduate Program at The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Science.

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