Overview

BetaSys uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.

Full Product Details

Author:   Bernhelm Booß-Bavnbek ,  Beate Klösgen ,  Jesper Larsen ,  Flemming Pociot
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2011 ed.
Volume:   v. 2
Dimensions:   Width: 15.50cm , Height: 3.80cm , Length: 23.50cm
Weight:   1.021kg
ISBN:  

9781441969552

ISBN 10:   1441969551
Pages:   556
Publication Date:   03 March 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Preface.- Systems biology of β-cells - revisited.- Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells – a background for a focused systems analysis approach.- Mitochondria and metabolic signals in β-cells.- β-cell ontogenesis and the insulin production apparatus.- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells.- The mathematical microscope making the inaccessible accessible.- Magnetic resonance imaging of pancreatic β-cells.- Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches.- In vivo applications of inorganic nanoparticles.- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts.- Bioimpedance spectroscopy.- DNA variations, impaired insulin secretion and type-2 diabetes.- Genetically programmed defects in β-cell function.- Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities.- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes.- Present state of islet transplantation for type-1 diabetes patients.- Predictive protein networks and identification of drugable targets in the β-cell.- Nanotoxicity.- From silicon cell to silicon human.- Probing cellular dynamics with mesoscopic simulations.- What drives calcium oscillations in β-cells? new tasks for cyclic analysis.- Whole-body and cellular models of glucose-stimulated insulin secretion.- Geometric and electromagnetic aspects of fusion pore making.- Index.

Reviews

From the reviews: “This second volume is Springer’s Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. … I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research.” (P. Meda, Diabetologia, Vol. 54, 2011)

From the reviews: This second volume is Springer's Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. ! I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research. (P. Meda, Diabetologia, Vol. 54, 2011)

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions