Overview

Beta cells or ss-cells, are a type of cell in the pancreas in areas called the islets of Langerhans. They make up 65-80% of the cells in the islets. Pancreatic B-cell is the only cell type that produces insulin to regulate glucose metabolism in the body. The insufficiency of insulin-producing B-cells results in dysregulation of blood glucose control, termed as type 1 diabetes. This book presents current research from across the globe in the study of Beta-cells, including the induction of pancreatic cancer cell death by elevated concentrations of extracellular zinc; the role of Rab GTPases and their effectors in the insulin secretory pathway of the pancreatic beta cell; In vivo reprogramming of pancreatic A-cells into B-like cells; and the role of glucocortoids, exercise and glucolipotoxicity with regard to stress and pancreatic B-cell function.

Full Product Details

Author:   Sarah E Gallagher
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   0.526kg
ISBN:  

9781617612121

ISBN 10:   161761212
Pages:   176
Publication Date:   24 May 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

Stress & Pancreatic ss Cell Function: Role of Glucocortoids, Exercise & Glucolipotoxicity; The Synergistic Effect of ss Cell Replacement & Immunotherapy on the Treatment of Type 1 Diabetes; Antagonizing the Endocannabinoid Pathway Prevents the Development of Diabetes & ss Cell Dysfunction in Zucker Diabetic Fatty Rats; Diabetes Mellitus: An Opportunity for Therapy with Regenerative Medicine?; Behind Beta Cell Glucotoxicity: A Pivotal Role of Glycoxidative Damage?; Induction of Pancreatic Cancer Cell Death by Elevated Concentrations of Extracellular Zinc; Rab GTPases Control Membrane Recycling in the Pancreatic Beta Cell; In Vivo Reprogramming of Pancreatic ?-cells into ss-like Cells; Studies of Toxin Resistant Beta-Cells: Lessons for the Chemotherapy?; Renin-Angiotensin System & Diabetes.

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