Overview

Before DNA revisits one of biology's deepest assumptions: that life began with a code. For decades, the origin of life has been framed as a problem of information-how molecules learned to replicate, store instructions, and evolve. But a code cannot function without stability, and chemistry cannot persist if energy overwhelms it. For the first time, life is examined from a regulation-first perspective - showing how stability, buffering, reconstruction, and prediction arise as physical necessities rather than evolutionary accidents. Drawing on thermodynamics, control theory, and modern physiology, Before DNA traces a continuous logic from prebiotic chemistry to living systems, biological diversity, and the emergence of mind. It reframes DNA not as a blueprint, but as a reconstruction constraint; explains why bacteria, fungi, plants, and animals represent distinct regulatory architectures; and shows how prediction, self-reference, and awareness arise when regulation turns inward. This perspective reshapes long-standing questions across disciplines: Origin of Life: from rare events to enduring architectures Biology: from lineage and genes to feasibility and constraint Medicine: disease as loss of regulatory coherence Mind: awareness as regulation made internal Astrobiology: life as sustained, buffered energy flow Before DNA does not add mystery to life. It removes it-revealing a quiet, universal coherence beneath living systems.

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