Overview

Bacterial pili play important roles as environmental sensors, in host colonization and in biofilm formation, enabling bacteria to interact with the environment, with surfaces and with other bacteria and host cells. Most bacteria, both Gram positive and Gram negative, and almost all bacterial pathogens, are piliated. This book discusses the synthesis, structure, evolution, function and role in pathogenesis of these complex structures, and their basis for vaccine development and therapeutics for Streptococcus pathogens. It is an invaluable resource for researchers and students of medical microbiology.

Full Product Details

Author:   Michele A Barocchi (Novartis Vaccines & Diagnostics Srl) ,  John Telford (formerly Novartis Vaccines & Diagnostics Srl, Italy)
Publisher:   CABI Publishing
Imprint:   CABI Publishing
ISBN:  

9781786395283

ISBN 10:   1786395282
Pages:   220
Publication Date:   22 October 2019
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

A: Table of Contents B: Foreword Sixty Years of Pilus research 1: The Vibrio cholerae toxin coregulated pilus: structure, assembly and function with implications for vaccine design 2: Conjugative pili 3: Pilus biogenesis by the chaperone-usher pathway 4: Type 1 and P Pili of Uropathogenic Escherichia coli 5: Type IV pili: functions and biogenesis 6: The Pseudomonas aeruginosa type IV pilus assembly system in three dimensions 7: Corynebacterium diphtheriae pili: Assembly, Structure, and Function 8: Three-dimensional structures of pilin subunits and their role in Gram-positive pilus assembly and stability 9: Sortase structure and specificity in Streptococci 10: Pili of Streptococcus pyogenes 11: The role of pili in the formation of biofilm and bacterial communities 12: Fimbrae/Pili from oral bacteria 13: Pilus based vaccine development in Streptococci: Variability, Diversity & Immunological responses

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Author Information

Michèle Anne Barocchi received her Ph.D. in Infectious Diseases and Immunity from the University of California, Berkeley in 2003. She has published over 45 peer reviewed papers, collaborated with WHO, The Gates Foundation and the United Nations on Sustainable Development Projects, and has spoken in numerous scientific conferences all over the world regarding health issues in developing countries. John L. Telford was formerly with Novartis Vaccines & Diagnostics Srl, Italy.

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