Overview

An exciting trend in B-cell biology is the growing recognition of the importance of natural antibodies to immune defence. B-1 cells are a substantial source of natural antibodies. This workshop brought together many of the leading people in this field to discuss the current status of B-1 cells, their developmental origin and their function. This field is still in its infancy and there is not yet universal agreement on how to define natural antibodies or B-1 cells. Many of the papers in this book address these issues. The association of B-1 cells and natural antibody producing cells to B-cell neoplasia are increasing. These are potentially important issues because of the increasing incidence of B-cell tumors in humans.

Full Product Details

Author:   M. Potter ,  F. Melchers
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2000 ed.
Volume:   v.252
Weight:   0.688kg
ISBN:  

9783540675679

ISBN 10:   3540675671
Pages:   341
Publication Date:   04 October 2000
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

I. B-1 Cells: Definition, Basic Hypotheses.-B-1 Cell Origins and V H Repertoire Determination.- II. B-1 Cells: Relationships to Pro B-Pre B Development and Negative Selection.- Response by B Cell Precursors to Pre-B Receptor Assembly: Differences between Fetal Liver and Bone Marrow.- B Cell Production and Turnover in CBA/Ca, CBA/N and CBA/N-bcl-2 Transgenic Mice: xid-mediated Failure among Pre B Cells is Unaltered by bcl-2 Overexpression.- Positive Selection of Low Affinity Autoreactive B Cells.- III. B-1 Cells and Positive Selection.- A Model for Autoantigen Induction of Natural Antibody Producing B-1a Cells.- The Role of Complement Receptors CD21/CD35 in Positive Selection of B-1 Cells.- Considerations on B Cell Homeostasis.- Selective Maturation of V H12 B Cells in the Spleen Enriches for Anti-Phosphatidyl Choline B Cells: Evidence for Receptor Editing.- CD5 and Other Superantigens May Select and Maintain Rabbit Self-renewing B-lymphocytes and Human B-CLL Cells.- Selection in the Mature B Cell Repertoire.- Immunoglobulin V H Gene Analysis in Rat: Most Marginal Zone B Cells Express Germline Encoded V H Genes and Are Ligand Selected.- IV. CD5.- STAT3 Activation, Chemokine Receptor Expression, and Cyclin-Cdk Function in B-1 Cells.- Role of NFAT in the Regulation of B-1 Cells.-Role of CD5 in Growth Regulation of B-1 Cells.- Life and Death Decisions in B1 Lymphoma Cells.- V. B-1 Cells in Inflammation.- The Role of B-1 and B-2 Cells in Immune Protection from Influenza Virus Infection.- B-1 B Cell IgM Antibody Initiates T Cell Elicitation of Contact Sensitivity.- Role of B Lymphocytes in Host Protection Against the Human Filarial Parasite, Brugia Malayi.- Neo-self Antigens and the Expansion of B-1 Cells: Lessons from Atherosclerosis-prone Mice.- B Cell Subsets in Pristane-induced Autoimmunity.- VI. B-1 Cells and Mucosal Immunity.- B-1 Cells and the Intestinal Microflora.- Mechanisms of B1 Cell Differentiation and Migration in GALT.- VII. B-1 Cells and Antibodies.- Early and Natural Antibodies in Non-mammalian Vertebrates.- Polyreactive Antibodies and Polyreactive Antigen-Binding B (PAB) Cells.- A B-Cell Superantigen that Targets B-1 Lymphocytes.- Myeloma Proteins that Bind Hap65 (GroEL) are Polyreactive and are Found in High Infidence in Pristance Inducted Plasmacytomas.- VIII. B-CLL and B-Cell Tumors.- Molecular Pathogenesis of B-Cell Chronic Lymphocytic Leukemia: Analysis of 13q14 Chromosomal Deletions.- Chronic Lymphocytic Leukamia: A Proliferation of B Cells at Two Distinct Stages of Differentiation.- Expression of Cyclooxygenase-2 and Prostaglandins by B-1 Cells and B-CLL Cells.- Diffuse Large-Cell and True Histiocytic Lymphomas of Mice.

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