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Diet is a major source of consumer exposure to pesticides, which have been linked to the development of metabolic disorders, carcinogenic effects, neurotoxicity, fertility issues, and a weakened immune system. The objectives of this study are to investigate the toxicity of certain pesticides commonly used for the phytosanitary treatment of food crops (in western Algeria), namely methibuzin (herbicide) and mancozeb (fungicide). To this end, the effects of the pesticides on the proliferation of human lymphocytes and rat splenocytes are determined in vitro. Additionally, the in vivo effects of low-dose, long-term (60-day) pesticide exposure on metabolism and the oxidative/antioxidant status in male and female rats are assessed. These pesticides have an immunomodulatory effect on T lymphocytes and on the oxidative/antioxidant balance, marked by an increase in biomarkers of oxidative stress and a decrease in antioxidant defenses, associated with metabolic abnormalities. It is therefore necessary to address the harmful effects of low doses of pesticides on our health.

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