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Author:   Luigi Di Costanzo
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
ISBN:  

9780443522338

ISBN 10:   0443522332
Pages:   258
Publication Date:   15 May 2026
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

Section I: Molecular and Structural Approaches to Arginase Function and Inhibition 1. Expression, Purification, and Structural Characterization of Human and Leishmania Arginase with Comparative Analysis of Structures from the Protein Data Bank E. D'Antonio, Luigi Franklin Di Costanzo and David W. Christianson 2. Synthesis of First-Generation Arginase Inhibitors F. Sodano 3. Computational and Structure-Guided Design of Arginase Inhibitors M.A. Fumagalli 4. Metal Substitution in Arginase: Experimental Approaches to Study Metal-Dependent Catalysis George Georgiou Section II: Advanced Therapeutic Strategies and Analytical Methods for Arginase 5. Therapeutic Arginase Formulations: PEGylation, Stability, and Advanced Delivery Systems L. Sloan and M. Rudebeck 6. Dual ARG1/ARG2 Inhibition: Experimental and Structural Strategies for Inhibitor Design and Optimization M. Grzybowski 7. Synthesis of Second-Generation Arginase Inhibitors F. Sodano 8. Cryo-EM Workflow and Structural Characterization of Arginase–Antibody Complexes G. Scapin 9. Development and Validation of an Electrochemical Assay for Arginase Activity A. Miglione, Luigi Franklin Di Costanzo and Stefano Cinti Section III: Clinical, Metabolic, and Translational Aspects of Arginase 10. Experimental and Structural Analysis of H. pylori Arginase in Gastric Immune Evasion A.K. Sau 11. Agmatinase and Alternative Arginine Utilization Pathways in Bacteria: Biochemical and Functional Perspectives J. French 12. Arginase Deficiency and Urea Cycle Disorders: Clinical and Metabolic Management N. Brunetti-Pierri 13. Inborn Errors of Metabolism and Arginine Pathways: Experimental and Clinical Approaches A. Schulze 14. Arginine Metabolism and Protein Balance: Experimental Approaches in Human Physiology M. P. K. J. Engelen 15. Arginase in Endothelial Dysfunction and Vascular Disease: Experimental and Translational Approaches W. Caldwell and R. Caldwell 16. Arginase in Cardiovascular and Vascular Inflammatory Disease W. Durante Section IV: Evolutionary and Functional Diversity of Arginase and Related Enzymes 17. Catalytic Diversification of the Arginase Fold: Structural and Mechanistic Insights from DcsB Y. Matoba and Kosuke Oda 18. Beyond Arginase: Structural Biology of the Extended Guanidinase Family G. Mlynek, S. V. Kundapura and D. Carugo 19. Plant Arginase: Structural and Functional Roles in Nitrogen Metabolism

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Author Information

Luigi F. Di Costanzo is a structural chemist and biochemist specializing in structural biology, enzymology, and protein science, with a focus on metalloenzymes and structure-based approaches to enzyme function and inhibition. He earned his Ph.D. in Chemistry from the Università degli Studi di Trieste (Italy) and completed postdoctoral training at the University of Pennsylvania, where he contributed to foundational studies on enzyme structure and inhibitor design. His research centers on the three-dimensional structure and mechanism of enzymes, with extensive experience in macromolecular crystallography, including structure determination, refinement, and analysis of protein–ligand complexes. His work integrates structural, biochemical, and biophysical approaches to understand enzyme function and guide therapeutic targeting. In addition to his research, he served for over a decade as a biocurator with the Worldwide Protein Data Bank (wwPDB) at the RCSB PDB (Rutgers University), contributing to the validation and annotation of more than 7,500 macromolecular structures. This work supported the integrity and reproducibility of structural biology data used by the global scientific community, including structural datasets that have contributed to the development of machine learning approaches to protein structure prediction, such as AlphaFold. His broader expertise includes multiscale structural characterization through complementary imaging and analytical techniques, including X-ray micro–computed tomography (µCT), linking atomic-level structure to complex biological systems, as well as contributions to community data resources, including the Protein Design Archive. As editor of the Methods in Enzymology volume “Arginase: Structure, Function, and Therapeutic Targeting,” he brings together structural, metabolic, and translational perspectives to advance the field.

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