ARF Family GTPases
Author:   Richard A. Kahn
Publisher:   Springer
Edition:   1st ed. Softcover of orig. ed. 2004
Volume:   1
ISBN:  

9789048164691


Pages:   350
Publication Date:   30 December 2010
Format:   Paperback
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

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ARF Family GTPases


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Overview

For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.

Full Product Details

Author:   Richard A. Kahn
Publisher:   Springer
Imprint:   Springer
Edition:   1st ed. Softcover of orig. ed. 2004
Volume:   1
Weight:   0.604kg
ISBN:  

9789048164691


ISBN 10:   9048164699
Pages:   350
Publication Date:   30 December 2010
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

The Arf Family Tree.- The GDP/GTP Cycle of Arf Proteins.- Arf and Phospholipids.- The Sec7 Family of Arf Guanine Nucleotide Exchange Factors.- Large Arf GEFs of the Golgi Complex.- BIG1 and BIG2: Brefeldin A-Inhibited Exchange Factors for Arfs.- Arf GTPase-Activating Protein 1.- GIT Proteins: Arf Gaps and Signaling Scaffolds.- Paxillin-Associated Arf GAPs.- Activation of Cholera Toxin and E. Coli Heat-Labile Enterotoxin (LT) by Arf.- Phospholipase D, Arfaptins and Arfophilin.- Coat Proteins.- Heterotetrameric Coat Protein-Arf Interactions.- Arf6.- A Role for Arf6 in G Protein-coupled Receptor Desensitization.- Arf-Like Proteins.

Reviews

From the reviews: A journey into a deeper understanding of the diversity of cellular controls exerted by the ARF family. The writing is so clear and well developed ! it will allow newcomers in the area to dive into a dynamic area of molecular and cellular science. ! the reader is treated to a wealth of discussion and critique on how ARFs modulate processes such as membrane fusion, vesicular transport, cell migration and receptor activity. This is an outstanding text for everyone with an interest in cell biology. (M. Thompson, Cell Biochemistry and Function, Vol. 23 (4), 2005)


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