Overview

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.

Full Product Details

Author:   Ariel Alonso (Maastricht University, Maastricht, Limburg, The Netherlands) ,  Theophile Bigirumurame ,  Tomasz Burzykowski (Hasselt University, Belgium) ,  Marc Buyse
Publisher:   Taylor & Francis Inc
Imprint:   Chapman & Hall/CRC
Weight:   0.715kg
ISBN:  

9781482249361

ISBN 10:   1482249367
Pages:   374
Publication Date:   08 December 2016
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introductory Material. Introduction. Notation and Example Datasets. The History of Surrogate Endpoint Validation. Contemporary Surrogate Endpoint Evaluation Methods. Multiple-Trial Surrogate Endpoint Evaluation Methods. Two Continuous Outcomes. Two Survival Endpoints. Two Categorical Endpoints. A Categorical and a Continuous Endpoint. A Survival and a Continuous Endpoint. A Survival and a Categorical Endpoint. Two Longitudinal Endpoints. A Longitudinal and a Survival Endpoint. Additional Considerations and Further Topics. Software Details. An Alternative Surrogate Endpoint Evaluation Framework: Causal-Inference. Surrogate Endpoint Evaluation Methods in Small Samples. Construction and Evaluation of Genetic Biomarkers in Early Drug Development Experiments. Additional Considerations.

Reviews

This is a timely text. The number of published studies using surrogate endpoints has increased dramatically since the early work of the 1980s; however, there is a dearth of available texts or software on this topic. Anyone with an interest in surrogate endpoint evaluation would benefit from this text. ~Statistics in Medicine

""This is a timely text. The number of published studies using surrogate endpoints has increased dramatically since the early work of the 1980s; however, there is a dearth of available texts or software on this topic. Anyone with an interest in surrogate endpoint evaluation would benefit from this text."" ~Statistics in Medicine

This is a timely text. The number of published studies using surrogate endpoints has increased dramatically since the early work of the 1980s; however, there is a dearth of available texts or software on this topic. Anyone with an interest in surrogate endpoint evaluation would benefit from this text. ~Statistics in Medicine

Author Information

Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst

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