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One finds here not only the final results illustrated frequently in colour images, but also the main steps of calculations in R with a possibility to access freely the software located somewhere in the cloud. The book represents an interesting and useful initiative and a tremendous work for putting all this together. It is also a testimony how much data analysis methods have widened and deepened in recent years. International Society for Clinical Biostatistics Statisticians, software specialists, and people in application fields address methodology and software development for big data and high-dimensional data in contexts where local patterns in a large data matrix are of primary interest. They describe biclustering methods for finding such patterns, and use the open-source statistics software R. The topics include from cluster analysis to biclustering, ensemble methods and robust solutions, biclustering methods in chemoinformatics and molecular modeling, overcoming data dimensionality problems in market segmentation, and biclustering for cloud computing. ProtoView A key feature of this book is the focus on R tools, with an emphasis on building a fully-functional and user-friendly data analysis solution.All presentedmethods are integrated into an R package BiClustGUI, which provides user-friendly interface and allows for the addition of custom extensions to the implemented methods. The book's website . . . provides a wealth of additional resources on biclustering, as well as links to all code implementation and data from the book. The chapter on cloud computing will be particularly useful to some readers, as it describes a portable implementation of a biclustering solution that integrates various previously introduced methods. In addition to replicating the results reported in the book, this section provides a blueprint for reproducible research. The American Statistician

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Adetayo Kasim is a senior research statistician at Durham University. Ziv Shkedy is a professor in the Interuniversity Institute for Biostatistics and Statistical Bioinformatics (I-BioStat) in the Center for Statistics at the University of Hasselt. Sebastian Kaiser is a professor in the Department of Statistics in the Faculty of Mathematics, Informatics and Statistics at Ludwig-Maximilians University of Munich. Sepp Hochreiter is a professor and head of the Institute of Bioinformatics at Johannes Kepler University Linz. Willem Talloen is a principal statistician at the Janssen Pharmaceutical Companies of Johnson & Johnson.

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