Overview

Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases.This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.

Full Product Details

Author:   Michael Jacobson (Millennium Pharmaceuticals Inc., Cambridge, MA, USA) ,  Nicola McCarthy (Division of Cardiovascular Medicine, Addenbrookes Hospital, Cambridge, UK) ,  Nicola McCarthy (Division of Cardiovascular Medicine, Addenbrookes Hospital, Cambridge)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   40
Dimensions:   Width: 19.50cm , Height: 2.40cm , Length: 25.30cm
Weight:   0.873kg
ISBN:  

9780199638505

ISBN 10:   0199638500
Pages:   346
Publication Date:   11 April 2002
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

1: Nicola McCarthy: Why be interested in death? 2: Ding Xue, Yi-Chun Wu, Manisha Shah: Programmed cell death in C.elegans: the genetic framework 3: Andreas Bergmann, Hermann Steller: Genetic and molecular analysis of programmed cell death in Drosophila 4: Natalie Roy, Michael Cardone: The caspases: from here to eternity 5: Yoshihide Tsujimoto: Regulation of apoptosis by the Bcl-2 family of proteins 6: Naoufal Zamzami, Santos Susin, Guido Kroemer: Mitochondria in apoptosis: Pandora's Box 7: Paul Clarke: Apoptosis: lessons from free cell systems 8: Nicola McCarthy, Martin Bennett: Death signalling by the CD95/TNFR family of death domain containing receptors 9: Thomas Franke: Survival signalling by phosphorylation: PI3K/Akt sets the stage 10: David Vaux: Viruses and apoptosis 11: Michael Jacobson, Louise Bergeron: Cell death in the nervous system

Reviews

[W]ell-written ... readable and thought provoking ... The editors each contribute excellent essays. --The Quarterly Review of Biology<br>

[W]ell-written ... readable and thought provoking ... The editors each contribute excellent essays. --The Quarterly Review of Biology [W]ell-written ... readable and thought provoking ... The editors each contribute excellent essays. --The Quarterly Review of Biology [W]ell-written ... readable and thought provoking ... The editors each contribute excellent essays. --The Quarterly Review of Biology [W]ell-written ... readable and thought provoking ... The editors each contribute excellent essays. --The Quarterly Review of Biology �W�ell-written ... readable and thought provoking ... The editors each contribute excellent essays. --The Quarterly Review of Biology

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