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Author:   Stanley T. Crooke
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1998
Volume:   131
Dimensions:   Width: 15.50cm , Height: 3.40cm , Length: 23.50cm
Weight:   0.997kg
ISBN:  

9783642637308

ISBN 10:   3642637302
Pages:   630
Publication Date:   08 October 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 Basic Principles of Antisense Therapeutics.- 2 Antisense Medicinal Chemistry.- 3 In Vitro Cellular Uptake, Distribution, and Metabolism of Oligonucleotides.- 4 Pharmacokinetic Properties of Phosphorothioates in Animals – Absorption, Distribution, Metabolism and Elimination.- 5 Toxicity of Oligodeoxynucleotide Therapeutic Agents.- 6 Pharmacokinetic Properties of Phosphorothioate Oligonucleotides in Immune Stimulation by Oligonucleotides in Humans.- 7 Safety and Tolerance of Phosphorothioates in Humans.- 8 Inmune Stimulation by Oligonucleotides.- 9 Pharmacological Inhibition of Dopaminergic and Other Neurotransmitter Receptors Using Antisense Oligodeoxynucleotides.- 10 Pharmacological Effects of Antisense Oligonucleotide Inhibition of Immediate-Early Response Genes in the CNS.- 11 Inhibition of G Proteins by Antisense Drugs.- 12 Use of Antisense Oligonucleotides to Modify Inflammatory Processes.- 13 Antisense Oligonucleotides and Their Anticancer Activities.- 14 Pharmacological Activity of Antisense Oligonucleotides in Animal Models of Disease.- 15 Clincial Antiviral Activities.- 16 Antisense Oligonucleotides to Protein Kinase C-a and C-raf Kinase: Rationale and Clinical Experience in Patients with Solid Tumors.- 17 Nucleic Acid Therapeutics for Human Leukemia: Development and Early Clinical Experience with Oligodeoxynucleotides Directed at c-myb.- 18 Properties of ISIS 2302, an Inhibitor of Intercellular Adhesion Molecule-1, Humans.- 19 Pharmacokinetics and Bioavailability of Antisense Oligonucleotides Following Oral and Colorectal Administrations in Experimental Animals.- 20 Antisense Properties of Peptide Nucleic Acid.- 21 Triple Helix Strategies and Progress.

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