Overview

This book presents a comprehensive and authoritative examination of one of the most significant global health challenges of the 21st century. This meticulously crafted volume brings together expert perspectives to address the complex and multifaceted nature of antimicrobial resistance (AMR). This book begins by establishing a solid foundation, exploring the history and science of antimicrobial resistance. It details the fundamental mechanisms through which bacteria, viruses, fungi, and parasites develop resistance to antimicrobial agents, providing readers with essential background knowledge. The evolution of resistance from a biological perspective is thoroughly examined, highlighting how microorganisms adapt and survive despite our medical interventions. Moving beyond scientific explanations, this book provides a global perspective on AMR prevalence, showcasing regional variations and trends. It offers an in-depth analysis of the primary drivers behind resistance development, including antibiotic misuse in human medicine, agricultural practices, environmental factors, and societal behaviors. The economic repercussions of AMR are comprehensively assessed, demonstrating its substantial impact on healthcare systems, national economies, and global development. A key strength of this volume is its adoption of the One Health approach, recognizing that human health is inextricably linked with animal health and environmental conditions. This integrated perspective highlights the interconnected nature of AMR and emphasizes the need for coordinated responses across sectors. This book dedicates significant attention to practical aspects of AMR management, including surveillance and monitoring systems, stewardship programs, and intervention strategies. It examines the current state of research and development for new antimicrobials, analyzing challenges in drug discovery and exploring innovative approaches to combat resistant infections. Policy dimensions receive thorough coverage through analysis of global action plans, national policies, and regulatory frameworks aimed at addressing AMR. Ethical considerations surrounding antimicrobial use, access disparities, and resource allocation are thoughtfully explored, providing a nuanced view of the moral dimensions of AMR management. Looking to the future, the volume presents potential scenarios and preparedness strategies, offering insights into how healthcare systems might adapt to increasing resistance. The book concludes with a powerful call to action, outlining specific roles and responsibilities for various stakeholders—from policymakers and healthcare professionals to pharmaceutical companies, agricultural sectors, and the general public.

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