Overview

Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging agents currently in development. Written by experienced professionals in the field, this guide uses an abundance of examples to depict methods to apply pharmacodynamic concepts to everyday clinical practice.

Full Product Details

Author:   Charles H. Nightingale ,  Paul G. Ambrose ,  George L. Drusano ,  Takeo Murakawa
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Edition:   2nd edition
Weight:   0.453kg
ISBN:  

9780367388966

ISBN 10:   0367388960
Pages:   536
Publication Date:   19 September 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction. Pharmacodynamics of Antimicrobials: General Concepts and Applications Impact of Pharmacodynamics on Breakpoint Selection for Susceptibility Testing. Non-Clinical Models of Infection. In Vitro Antibiotic Pharmacokinetic Models. Animal Models of Infection for the Study of Antibiotic Pharmacodynamics. The Predictive Value of Laboratory Tests for Efficacy of Antibiotic Combination Therapy. Antibacterial Agents. Beta-Lactam Antibiotics. Aminoglycoside Antibiotics. Quinolones. Glycopeptides. Macrolide, Azalide and Ketolides. Metronidazole, and Clindamycin. Streptogramins, Oxazolididones. Tetracyclines. Antiviral Agents. Nucleoside Reverse Transcriptase Inhibitors. Protease Inhibitors. Hepatitis B and C. Antifungal Agents. Amphotericin. Azoles. Gulcan Synthase Inhibitors. Antimalarial Agents. Anti-Malarials. Pharmacodynamics in Drug Development. Human Pharmacodynamics of Anti-Infectives: Determination from Clinical Trial Data. Pharmacodynamics in Global Bridging Studies. Toxicodynamics. Pharmacodynamics and Resistance. Antibacterial Resistance. Application of PK-PD to Clinical and Formulary Decisions. Basic Pharmacoeconomics. Utilizing Pharmacodynamics and Pharmacoeconomics in Clinical and Formulary Decision Making.

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Nightingale, Charles H.; Ambrose, Paul G.; Drusano, George L.; Murakawa, Takeo

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