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Author:   Paul Cotter (Moorepark Food Research Centre, Ireland) ,  Guangshun Wang (University of Nebraska Medical Center, Omaha, Nebraska) ,  Guangshun Wang (University of Nebraska Medical Center, Omaha, Nebraska) ,  David Craik (University of Queensland, Australia)
Publisher:   CABI Publishing
Imprint:   CABI Publishing
Edition:   18th
Volume:   No.18
Dimensions:   Width: 17.20cm , Height: 2.00cm , Length: 24.40cm
Weight:   0.740kg
ISBN:  

9781845936570

ISBN 10:   1845936574
Pages:   240
Publication Date:   11 May 2010
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

A: Preface B: Introduction Part I: Natural Antimicrobial Peptides: Nomenclature, Classification, and Interesting Templates for Peptide Engineering 1: A Database View of Naturally Occurring Antimicrobial Peptides: Nomenclature, Classification and Amino Acid Sequence Analysis 2: Lantibiotic-related Research and the Application thereof 3: Antimicrobial Peptides in Plants Part II: Expanding the Peptide Space: Prediction Methods, Design Strategies, and Peptidomimetics 4: Database-aided Prediction and Design of Novel Antimicrobial Peptides 5: Discovery of Novel Antimicrobial Peptides Using Combinatorial Chemistry and High-Throughput Screening 6: Chemical Mimics with Systemic Efficacy Part III: Biophysics, Structural Biology and Mechanism of Action of Antimicrobial Peptides 7: Biophysical Analysis of Membrane-Targeting Antimicrobial Peptides: Membrane Properties and the Design of Peptides Specifically Targeting Gram-negative Bacteria 8: Non-membrane Targets of Antimicrobial Peptides: Novel Therapeutic Opportunities? 9: Structural Studies of Antimicrobial Peptides Provide Insight into Their Mechanisms of Action Part IV: Novel Therapeutic Strategies to Bolster Host Defence 10: Lung Infection: Shifting the Equilibrium toward the Free and Active Form of Human LL-37 and the Design of Alternative Antimicrobial Agents 11: Role of Vitamin D in the Enhancement of Antimicrobial Peptide Gene Expression 12: Fine Tuning Host Responses in the Face of Infection: Emerging Roles and Clinical Applications of Host Defence Peptides

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Author Information

Dr. Guangshun Wang, trained as a chemist in China at Yangzhou University and the Chinese Academy of Sciences, obtained his Ph.D. in Biophysical Chemistry from Simon Fraser University, Canada in 1997. He then did his postdoctoral stints at the Florida State University and at the National Institutes of Health, USA with a focus on structural biology of signal-transducing protein-protein complexes by NMR spectroscopy. In 2002, he joined the faculty of the University of Nebraska Medical Center (Omaha, USA). His research interests include structural, bioinformatic, and functional studies of host defense antimicrobial peptides (http://aps.unmc.edu/AP/main.html) and their potential applications that benefit human beings. Dr. Wang has published more than 50 original papers, review articles, and book chapters. He has one US patent granted and two pending. He currently serves as an editor for the Open Journal of Magnetic Resonance and sits on the editorial board of several other journals.

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