Overview

This book is dedicated to the antibiotics Aminosides & Quinolones, which are of particular importance in the management of urinary tract infections, bone infections, intra-abdominal infections, bronchopulmonary infections, ENT infections, etc. Aminosides are first-line parenteral bactericides for severe aerobic Gram-negative infections. Quinolones are rapid, concentration-dependent bactericides with a broad antibacterial spectrum.Two chapters are described in this volume: Aminosides & Quinolones. Each chapter successively covers: History of discovery, pharmaco-chemical classification and main marketed molecules; Study of the leader for each class, i.e. its chemical synthesis and quality control; Mechanism of action on a molecular scale and Study of the chemical structure-therapeutic activity relationship; Main indications, undesirable effects and contraindications.

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