Overview

Since the 1940s, a variety of antibacterial substances have been discovered, designed and synthesized. The worldwide anti-infective market is now approaching $20 billion dollars annually, and antibacterial agents comprise the bulk of this trade. Several general classes of antibacterial drugs have emerged as mainstays in modern infectious disease chemotherapy. This work provides an introduction at research level to all the basic classes of antibacterial agents, with a discussion of their basic chemistry, pharmacology, molecular mode of action and synthetic approaches.

Full Product Details

Author:   S.L. Dax
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Edition:   1997 ed.
Dimensions:   Width: 15.60cm , Height: 2.40cm , Length: 23.40cm
Weight:   0.940kg
ISBN:  

9780751402896

ISBN 10:   0751402893
Pages:   416
Publication Date:   31 October 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Introduction.- 1.1 History and overview of anti-infective chemotherapy.- 1.2 Infectious disease outbreaks and plagues.- 1.3 Common bacterial species.- 1.4 Sources of chemotherapeutic antibacterial agents and the impact of organic chemistry.- 1.5 Resistance.- 1.6 Current status and trends in antibacterial chemotherapy.- Further reading.- 2 Sulfa antibacterials and arylpyrimidine antifolates.- 2.1 History and overview.- 2.2 Mode of action: inhibition of bacterial folate metabolism.- 2.3 Structural features and structure-activity relationships of the sulfa antibacterials and arylpyrimidine antifolates.- 2.4 Synthetic approaches to sulfa antibacterials and arylpyrimidine antifolate antibacterial agents.- 2.5 Bacterial resistance to the sulfa antibacterials and arylpyrimidine antifolates.- 2.6 New agents.- 2.7 Summary.- Further reading.- 3 ß-Lactam antibiotics.- 3.1 History and overview.- 3.2 Mode of action: penicillin-binding proteins and inhibition of transpeptidation.- 3.3 Structural features and structure-activity relationships of the ß-lactam antibacterials.- 3.4 Synthesis of ß-lactam antibacterials.- 3.5 Bacterial resistance to the ß-lactam antibacterial agents.- 3.6 Recent advances.- 3.7 Summary.- Further reading.- 4 Tetracycline antibiotics.- 4.1 History and overview.- 4.2 Mode of action: bacterial protein synthesis inhibition.- 4.3 Structural features and structure-activity relationships of the tetracycline antibacterials.- 4.4 Synthetic approaches to tetracycline antibacterial agents.- 4.5 Uptake and bacterial resistance to tetracycline antibacterial agents.- 4.6 Recent advances.- 4.7 Summary.- Further reading.- 5 Aminoglycoside antibiotics.- 5.1 History and overview.- 5.2 Mode of action: bacterial protein synthesis inhibition.- 5.3 Structural features andstructure-activity relationships of the aminoglycoside antibacterials.- 5.4 Synthetic approaches to aminoglycoside antibacterial agents.- 5.5 Bacterial resistance to aminoglycoside antibacterials.- 5.6 Recent advances.- 5.7 Summary.- Further reading.- 6 The non-peptidic macrocyclic antibacterials.- 6.1 History and overview.- 6.2 Mode of action of the non-peptidic antibacterials.- 6.3 Structural features and structure-activity relationships of the macrocyclic antibacterials.- 6.4 Synthetic approaches to the non-peptidic macrocyclic antibacterials.- 6.5 Bacterial resistance to non-peptidic macrocyclic antibacterial agents.- 6.6 Recent advances.- 6.7 Summary.- Further reading.- 7 Quinolone antibacterials.- 7.1 History and overview.- 7.2 Mode of action: bacterial DNA gyrase inhibition.- 7.3 Structural features and structure-activity relationships of quinolone antibacterials.- 7.4 Synthetic approaches to quinolone antibacterial agents.- 7.5 Bacterial resistance to quinolone antibacterials.- 7.6 Recent advances.- 7.7 Summary.- Further reading.- 8 Peptidic antibacterial agents.- 8.1 Introduction.- 8.2 Individual peptidic antibacterial compounds.- 8.3 General comments.- Further reading.- 9 Miscellaneous antibacterial agents.- 9.1 Chloramphenicol.- 9.2 Lincosamides.- 9.3 Nitrofurans and nitroimidazoles.- 9.4 Vancomycin and teicoplanin.- 9.4.1 Mode of action.- 9.5 Isoniazid and other antituberculosis agents.- Further reading.

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