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This study investigated the probiotic potential of Lactobacillus isolates from infants' feces and their antimicrobial activity against burn wound pathogens, particularly antibiotic-resistant Pseudomonas aeruginosa. 70 burn wound isolates from Al-Sadr Medical City and Al-Forat Hospital were identified, with P. aeruginosa (35.7%), S. aureus (25.7%), and K. pneumoniae (18%) most prevalent. Antibiotic resistance genes bla-TEM, bla-GES, bla-OXA, and bla-SHV were detected using PCR. 120 fecal samples from infants under 2 years yielded 57 Lactobacillus isolates, of which 10 showed strong antibacterial activity. All tolerated acid (pH 2.5) and bile (0.3%), with Isolate 10 showing 98.5% pH tolerance and 82% bile tolerance. MIC and MBC against P. aeruginosa were 256 µl/ml and 512 µl/ml, respectively. The isolates inhibited growth and biofilm formation of P. aeruginosa by 98.3%. 16S rRNA sequencing identified 5 L. acidophilus, 4 L. helveticus, and 1 Lactobacillus sp. These findings indicate Lactobacillus spp. could be a promising probiotic agent for controlling antibiotic-resistant burn wound infections.

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