Overview

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions.  Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant.  In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis.  While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized.  The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment;  c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment;  e. regulation by EMT.

Full Product Details

Author:   Steven M. Frisch
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2021
Weight:   0.489kg
ISBN:  

9783030738549

ISBN 10:   303073854
Pages:   202
Publication Date:   28 July 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

PrefaceIntroduction Chapter 1 The intersection of anoikis resistance and fatty acid metabolism in cancerChapter 2 Anoikis resistance in melanomaChapter 3 Anoikis mediated by stress-activated MAPK signaling pathwaysChapter 4 Metabolic Regulation of AnoikisChapter 5 Metabolic Reprogramming contributes to Anoikis resistance in Cancer CellsChapter 6 Role of the nuclear receptors in anoikisChapter 7 The roles of anoikis in cervical cancerChapter 8 Shc and the control of small GTPase dynamics in cellular anchorageChapter 9 Anoikis and the Human Gut Epithelium in Health and DiseaseChapter 10 Epithelial cell extrusion: the prelude to anoikisChapter 11 Microtubule modifications and mitochondria: role in anoikis

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Author Information

Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.

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