Overview
Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field.
Full Product Details
Author: Asfar Azmi (Assistant Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA) ,
Ramzi M. Mohammad (Professor, Department of Oncology, Director GI Research, Wayne State University and Karmanos Cancer Institute, USA)
Publisher: Elsevier Science Publishing Co Inc
Imprint: Academic Press Inc
Weight: 1.060kg
ISBN: 9780128147047
ISBN 10: 0128147040
Pages: 470
Publication Date: 17 April 2019
Audience:
Professional and scholarly
,
College/higher education
,
Professional & Vocational
,
Postgraduate, Research & Scholarly
Format: Paperback
Publisher's Status: Active
Availability: Manufactured on demand
We will order this item for you from a manufactured on demand supplier.
Author Information
Asfar Azmi, PhD, is an Assistant Professor at the Department of Oncology, Wayne State University. He has more than a decade of research experience in the area of cancer biology and drug discovery. Dr. Azmi’s lab has made significant pre-clinical discoveries in advanced animal tumor models that helped the clinical development of new cancer drugs. Dr. Azmi has considerable experience in the area of early phase clinical research. Several agents developed by his team have gone into Phase II clinical studies. He has published more than 100 cancer research articles and has edited three additional books, among which there are the Elsevier publications Molecular Diagnostics and Treatment of Pancreatic Cancer as well as Conquering Ras. He is the recipient of numerous young investigator awards from premier scientific bodies. The National Institute of Health and pharmaceutical industry have continuously funded his lab. Ramzi M. Mohammad, PhD, is a Professor at the Department of Oncology and Director of GI Research for the Karmanos Cancer Institute, Wayne State University, USA. Dr. Mohammad has more than 25 years of cancer research experience, including extensive experience in animal models. He has established several tumor models of pancreatic cancers and Non-Hodgkin’s lymphoma. He was among the first to establish pancreatic orthotopic models. The cell lines and tumors models developed by Dr. Mohammad are in extensive use worldwide for studying new anticancer agents.
