Overview

Angiotensin-converting enzyme (ACE) is a well-known zinc-metallopeptidase that converts angiotensin I to the potent vasoconstrictor angiotensin II and degrades bradykinin, a powerful vasodilator, both for the regulation of vascular tone and cardiac functions. Other natural substrates of ACE were identified broadening the functions of this enzyme within different physiological contexts such as neuronal metabolism, hematopoiesis, digestion, and reproduction. In this context, ACE has an essential role in diseases, for instance, hypertension, Alzheimer's disease, oxidative stress, sperm maturation and fertility, intraocular pressure, bone metabolism, fibrillary glomerulonephritis, among others. This book describes the role of ACE as a part of the Renin-Angiotensin-System, on different metabolic processes related to some diseases, such as the examples already mentioned. Moreover, ACE is related to adipose tissue. The modulation of ACE can modulate hypertension and diseases related to this enzyme. Captopril is the first successful ACE inhibitor in the treatment of hypertension; however, it has adverse effects such as dry cough, dizziness, lightheadedness or loss of taste and others. The search for alternatives to Captopril has increased research on bioactive peptides. Then, several book chapters describe how ACE can be modulated by bioactive peptides, which are short amino acid sequences previously encrypted in whole proteins and liberated through the digestion process. Animal and vegetal proteins can be used as a source of bioactive peptides. Milk, milk-derived food products and lionfish are examples of animal proteins, while several legumes such as beans and peanuts are vegetable sources of bioactive peptides.

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9781536172492

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Acknowledgements; Renin-Angiotensin-Aldosterone System and Oxidative Stress; The role of the angiotensin-converting enzyme in male reproduction and fertility from experimental models to clinical studies; A review of the effects of Angiotensin and Angiotensin-converting enzyme and/or angiotensin receptor inhibition on airway and respiratory mechanics in respiratory disease and healthy subjects; The perspectives of the topical use of inhibitors of the angiotensin-converting enzyme for the treatment of eye diseases accompanied by ischemia and increased intraocular pressure; Anti-Obesity and antihypertensive peptides: its relationship to adipose tissue; Angiotensin-1- converting enzyme inhibition by bioactive peptides from milk proteins; Fatty acids and bio-peptides from chia seeds: a new alternative for the control of the Angiotensin-Converting Enzyme; Inhibitory effect of angiotensin-converting enzyme and antioxidant capacity of Panela type cheeses; Angiotensin-Converting Enzyme Control Mediated by Phenolic Compounds; Angiotensin inhibitory peptides derived from legume seeds proteins; Inhibition of angiotensin converting enzyme (ACE) by peptide fractions obtained from lionfish (Pterois volitans L.) muscle hydrolysates; Modulation of Angiotensin-1-converting enzyme by bioactive peptides from animal and vegetal origin; The genus Phaseolus as a source for ACE inhibitory peptides; Obtainment and characterization of bioactive peptides with antihypertensive activity of peanut (Arachis hypogaea) protein hydrolysates; The action of the Renin-Angiotensin System on Bone Metabolism; The role of angiotensin-converting enzyme in hypertension; Potential effects of Renin-Angiotensin-Aldosterone System (RAS) blockers in the treatment of fibrillary glomerulonephritis (FGN); Index.

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