Overview

This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions. 

Full Product Details

Author:   Ali Salajegheh
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   6.672kg
ISBN:  

9783319802817

ISBN 10:   331980281
Pages:   423
Publication Date:   25 April 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Introduction to Angiogenesis in Normal Physiology. Disease and Malignancy 2. Adenosine triphosphate-binding cassette (ABC) lipid transporters 3. Angiogenin 4. Angiopoietins 5. Angiotropin  6. C-KIT: tyrosine kinase receptors with potential to initiate  7. CCND1 and E1 8. Cluster of Differentiation 71 (CD71) 9. Connective Tissue Growth Factor (CTGF)  10. COX10 11. Cysteine-rich 61 (Cyr61) 12. Epidermal growth factor 13. Epidermal growth factor domain-like 7 (EGFL7)  14. Erythropoietin-producing hepatocellular receptors A: Ephrin A1, Ephrin A2 and Ephrin A3 15. Erythropoietin-producing hepatocellular receptors B: Ephrin B2, Ephrin B4 16. Ets-1 17. Fibrin 18. Fibroblast growth factors (Acidic: FGF-1; Basic: FGF-2) and its receptors (FGFR) 19. Fibronectin 20. Granulocyte-Macrophage and Granulocyte Colony Stimulating Factor (GM-CSF and G-CSF) 21. GAX and HOXA5 22. Heparanase 23. Hepatocyte Growth Factor (HGF) 24. HIF-1α 25. Insulin-like growth factor 26. Integrins (αv1β3, αv1β5, β8) 27. Interleukins 28. Insulin receptor substrate (IRS1) 29. Iron-sulfur clusters (ISCU) 30. MDM4 31. Matrix Metalloproteinase 2 (MMP2)         32. Monobutyrin 33. Neutrophil activating protein-2 (NAP-2) 34. p27kip1 and p57Kip2 (CDKN1B and CDKN1C) 35. Platelet-derived endothelial cell growth factor (PDGF) 36. Prolyl hydroxylase domain-2  (PHD-2) 37. Phosphatidylinositol-4, 5-bisphosphate 3-kinase (PIK3Ca)  38. PIK3R2 (p85β) - Phosphatidylinositol 3-kinase β-subunit 39. Platelet-activating factor 40. Placenta growth factor (PlGF) 41. Preproendothelin-1 (PreproET-1)  42. Proliferin 43. Prostaglandins 44. ROS1 45. SIRT1 46. SMAD4 (Mothers against Decapentaplegic Homolog 4) 47. Sprouty-Related, EVH1 Domain-containing protein 1 (SPRED-1) 48. Signal transducer and activator of transcription of 5A and S3 (STAT5 and STATS3) 49. SUFU 50. Tenascins 51. Tissue inhibitor of metalloproteinases 1 and 2 (TIMP-1 and TIMP-2) 52. Tissue factor  gene 53. Transforming growth factor α and β (TGF- α and TGF- β)  54. Transforming growth factor beta-receptor type II (TGFβR2)  55. TSP-1 56. Tumour necrosis factor-α (TNF-α)  57. Urokinase plasminogen activator  58. Vascular Endothelial Growth Factor (VEGF)  59. Vascular cell adhesion molecule-1 (VCAM-1) 60. Vascular endothelial (VE)-Cadherin 61. Zinc Finger E-Box Binding Homeobox 1 (ZEB1) 62. Miscellaneous genes involved in Angiogenesis in Normal Physiology, Disease and Malignancy

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