Overview

An introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and Web sites. Each chapter ends with a set of problems, the solutions to which are found at the back of the book. New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of non-parametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits.

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9780801861406

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Reviews

<p>For the last decade this book has been the unrivaled standard text on human genetic linkage analysis.--J.H. Barrett Biometrics

A valuable resource. It is the most accessible work on the subject, and should be in the collection of everyone interested in mapping human genes. * Doody's Book Review * For the last decade this book has been the unrivaled standard text on human genetic linkage analysis. -- J.H. Barrett * Biometrics * One of the best books that cover the theory behind linkage analysis. Scientists with an interest in genetic linkage analysis should definitely consider allocating space on their bookshelves for this book. * Biotech Software and Internet Report *

<p> One of the best books that cover the theory behind linkage analysis. Scientists with an interest in genetic linkage analysis should definitely consider allocating space on their bookshelves for this book. -- Biotech Software and Internet Report

Author Information

Jurg Ott is a professor and head of the Laboratory of Statistical Genetics at Rockefeller University. He is editor-in-chief of Human Heredity and the author of the first generally available computer program on human linkage analysis (LIPED).

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