Overview

Preimplantation genetic diagnosis (PGD), the detection of incipient disease in embryos prior to implantation in the womb, is a fast-growing and complex field of research that is rapidly entering everyday clinical practice. This extensively illustrated atlas provides a detailed manual for the establishment and realization of PGD within the framework of assisted reproduction and genetics services. This fully revised and updated volume presents knowledge based on the world's largest PGD experience of more than 2000 cycles performed for 100 different genetic conditions. The atlas includes descriptions of the authors' pioneering work of polar body based PGD for genetic and chromosomal disorders, the use of nuclear transfer techniques for PGD for translocations, and preimplantation human leukocyte antigen (HLA) typing. Although still controversial, the authors' novel experience of PGD for late-onset disorders with genetic predisposition will be of special interest. Finally, presentation of the authors' largest accumulated PGD experience for poor-prognosis IVF patients, provides further evidence of the improvement of clinical outcome, and the requirement for meiotic error testing for a higher accuracy of preselecting aneuploidy-free embryos for transfer. Written from one of the world's leading centers of excellence in these techniques, the atlas offers a practical guide to safe, accurate and reliable PGD. The illustrations from the first edition, clearly demonstrating the full range of techniques for PGD, have been supplemented with more than 100 unique new images including preimplantation diagnosis for aneuploidies, translocations and single gene disorders. This makes the book of practical usefulness for reproductive medicine and genetics practices, and an invaluable aid for all those involved in human reproduction.

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9781842142455

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Read the reviews of the first edition: The Atlas is technically detailed and beautifully illustrated. --Joy Delhanty, Journal of Medical Geneitcs The book's raidon d'etre is its 119 pages of color illustrations. Too effusive praise cannot be given for these illustrationsthe book should be on the shelf of every prenatal genetic and IVF unit. --Joe Leigh Simpson, Fertility and Sterility An extraordinary documentation on chromosomal analysis with the fluorescent in situ hybridization technique describes the results by preimplantation genetic diagnosis for aneuploidy in oocytes and embryos, including translocation casesThe reading of this book yields a clear picture of the current status of preimplantation genetic diagnosiswill certainly support embyologists, gynecologists, and andrologists in understanding the reationale of this approach. --Organon's Magazine on Women and Health it will enable the clinician to understand better the complexity of the task facing the laboratoty professionals when a patient is referred for genetic diagnosis before the embryo implants. --Journal of Medical Genetics Preimplantation genetic diagnosis is now applied successfully to the detection of more and more severe forms of inherited diseaseIts advanced technologies are well illustrated in the pictures and text so carefully gathered in this book

Praise for the First Edition: The Atlas is technically detailed and beautifully illustrated. -Joy Delhanty, Journal of Medical Genetics The book's raison d'etre is its 119 pages of color illustrations. Too effusive praise cannot be given for these illustrations ... the book should be on the shelf of every prenatal genetic and IVF unit. -Joe Leigh Simpson, Fertility and Sterility An extraordinary documentation on chromosomal analysis with the fluorescent in situ hybridization technique ... yields a clear picture of the current status of preimplantation genetic diagnosis ... will certainly support embyologists, gynecologists, and andrologists in understanding the reationale of this approach. -Organon's Magazine on Women and Health ... will enable the clinician to understand better the complexity of the task facing the laboratory professionals when a patient is referred for genetic diagnosis before the embryo implants. -Journal of Medical Genetics

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