Overview

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Full Product Details

Author:   Maria M. Picken ,  Ahmet Dogan ,  Guillermo A. Herrera
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2012
Dimensions:   Width: 17.80cm , Height: 3.00cm , Length: 25.40cm
Weight:   1.022kg
ISBN:  

9781607613886

ISBN 10:   1607613883
Pages:   425
Publication Date:   03 April 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Temporarily unavailable  
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Table of Contents

Section 1 Introduction/General : 01.Aspects of the History and Nomenclature of Amyloid and Amyloidosis - Per Westermark 02.Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis - Mario Nuvolone, Giovanni Palladini, Giampaolo Merlini 03. AA Amyloidosis- Amanda K. Ombrello, Ivona Aksentijevich 04. The Hereditary Amyloidoses- Merrill D. Benson 05.Dialysis-Associated Amyloidosis- Paweena Susantitaphong, Laura M. Dember, Bertrand L. Jaber 06.Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System- Per Westermark 07.Cerebrovascular Amyloidoses- John M. Lee, Maria M. Picken Section 2 Non-Amyloid Protein Deposits : 08. Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis- Guillermo A. Herrera, Elba A. Turbat-Herrera 09.Light / Heavy Chain Deposition Disease as a Systemic Disorder- Guillermo A. Herrera, Elba A. Turbat-Herrera 10. Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits- Pierre Ronco, Alexandre Karras, Emmanuelle Plaisier 11.Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond- Maria M. Picken Section 3 Diagnosis : 12.Diagnosis of Amyloid Using Congo Red- Alexander J Howie 13.Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method - A Review- Reinhold P. Linke 14.Thioflavin T stain - An Easier and More Sensitive Method for Amyloid Detection- Maria M. Picken and Guillermo A. Herrera 15.Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis - Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg 16.Generic Diagnosis of Amyloid - a Summary of Current Recommendations and the Editorial Comments on Chapters 12 - 15.- Maria M. Picken 17.Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohistochemistry- Reinhold P. Linke 18.Amyloid Typing - Experience from a Large Referral Centre - Janet A Gilbertson, Toby Hunt, Philip N. Hawkins 19.Options for Amyloid Typing in Renal Pathology - the Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohistochemistry (Chapters 17 - 19)- Maria M. Picken 20.Amyloid Typing: Immuno-Electron Microscopy - Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Vittorio Necchi, Marco Paulli, Giampaolo Merlini 21.Classification of Amyloidosis by Mass Spectrometry Based Proteomics.- Ahmet Dogan Section 4 Ancillary Studies of Amyloidosis : 22.Laboratory Support for Diagnosis of Amyloidosis- David L Murray, Jerry A. Katzmann, 23.Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias- Sujata Ramamurthy, Lawreen H. Connors, Carl J. O'Hara 24.Laboratory Methods for the Diagnosis of Hereditary Amyloidoses- S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr. Section 5 Organ Involvement in Amyloidoses : 25.Amyloidoses of the Kidney and Genitourinary Tract- Maria M Picken 26.Cardiac Amyloidoses- Carmela D. Tan, E. Rene Rodriguez 27.Amyloidosis of the Gastrointestinal Tract and Liver- Oscar W. Cummings, Merrill D. Benson 28.Peripheral Nerve Amyloidosis- Adam J. Loavenbruck, Janean K. Engelstad, Christopher J. Klein Section 6 Clinical Issues and Therapy : 29.Clinical and Pathologic Issues in Patients with Amyloidosis - Practical Comments Regarding Diagnosis, Therapy and Solid Organ Transplantation- Jay Dalal, Kevin Barton, Maria M. Picken 30.Emerging Therapies for Amyloidosis- Merrill D. Benson 31.Modern Therapies in AA Amyloidosis- Amanda K. Ombrello, 32.Medicolegal Issues of Amyloidosis- Timothy Craig Allen 33.Amyloidosis from the Patient's Perspective- Muriel Finkel

Reviews

From the reviews: This comprehensive book is the first to integrate the clinical and pathological aspects of the diagnosis and treatment of amyloid and related disorders. ... It is written primarily for pathologists, but it also includes relevant information for clinical practitioners interested in the early diagnosis of amyloidoses. ... Overall this is a comprehensive, well-written, and clinically pertinent reference on amyloidosis and related disorders. ... The color images supplement well the detailed text, making it an excellent resource for pathologists as well as clinicians. (Melissa S. Jacobs, Doody's Review Service, August, 2012)

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