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Author:   Don T Elmore ,  J S Davies (University of Wales) ,  Imre Sovago (University of Debrecen) ,  Etelka Farkas (University of Debrecen, Hungary)
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 35
Dimensions:   Width: 15.60cm , Height: 3.40cm , Length: 23.40cm
Weight:   1.793kg
ISBN:  

9780854042470

ISBN 10:   0854042474
Pages:   472
Publication Date:   12 September 2006
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Chapter 1: Amino Acids; 1: Introduction; 2: Reviews; 3: Naturally Occurring Amino Acids; 3.1: New Naturally Occurring Amino Acids; 4: Chemical Synthesis and Resolution of Amino Acids; 4.1: General Methods for the Synthesis of ?-Amino Acids Including Enantioselective Synthesis; 4.2: Synthesis of Protein Amino Acids and Other Naturally Occurring Amino Acids; 4.3: Synthesis of ?-Alkyl and ?-Amino Acids; 4.4: Synthesis of ?-Amino Acids with Acyclic and Long Aliphatic Side Chains; 4.5: Models for Prebiotic Synthesis of Amino Acids; 4.6: Synthesis of Halogenoalkyl ?-Amino Acids; 4.7: Synthesis of Hydroxyalkyl ?-Amino Acids; 4.8: Synthesis of N-Substituted ?-Amino Acids; 4.9: Synthesis of ?-Amino Acids carrying Unsaturated Aliphatic Side-chains; 4.10: Synthesis of ?-Amino Acids with Aromatic or Heterocyclic Side-chains; 4.11: Synthesis of ?-Amino Acids Carrying Amino Groups and Related Nitrogen Functional Groups in Aliphatic Side Chains; 4.12: Synthesis of ?-Amino Acids with Side-chains Carrying Boron Functional Groups; 4.13: Synthesis of ?-Amino Acids with Side-chain Carrying Silicon Functional Groups; 4.14: Synthesis of ?-Amino Acids with Side-chains Carrying Phosphorus Functional Groups; 4.15: Synthesis of ?-Amino Acids with Side-chains Carrying Sulfur and Selenium; 4.16: Synthesis of ?-Amino Acids with Higher Homologous Amino Acids; 4.17: Resolution of DL-Amino Acids; 5: Physico-chemical Studies of Amino Acids; 5.1: X-ray Crystal Analysis of Amino Acids and Their Derivatives; 5.2: Nuclear Magnetic Resonance Spectroscopy; 5.3: Circular Dichroism; 5.4: Mass Spectrometry; 5.5: Other Spectroscopic Studies on Amino Acids; 5.6: Measurements on Amino Acids in Solution; 5.7: Measurements on Amino Acids in the Solid State; 5.8: Amino Acids Absorption and Transport Phenomena; 5.9: Host-Guest Studies with Amino Acids; 5.10: Theoretical Calculations involving Amino Acids; 6: Reactions and Ananlysis of Amino Acids; 6.1: General and Specific Reactions of Amino Acids; 6.2: Analysis of Amino Acids; References; Chapter 2: Peptide Synthesis; 1: Introduction; 2: Methods; 2.1: Amino-group Protection; 2.2: Carboxy-group Protection; 2.3: Side-chain Protection; 2.4: Disulfide Bond Formation; 2.5: Peptide Bond Formation; 2.6: Peptide Synthesis on Macromolecular Supports and Methods of Combinatorial Synthesis; 2.7: Enzyme-mediated Synthesis and Semi-synthesis; 2.8: Miscellaneous Reactions Related to Peptide Synthesis; 3: Appendix: A List of Syntheses in 2002; 3.1: Natural Peptides, Proteins and Partial Sequences; 3.2: Sequential Oligo- and Poly-peptides; 3.3: Enzyme Substrates and Inhibitors; 3.4: Conformations of Synthetic Peptides; 3.5: Glycopeptides; 3.6: Phosphopeptides and Related Compounds; 3.7: Immunogenic and Immunosuppressant Peptides; 3.8: Nucleopeptides, PNAs; 3.9: Miscellaneous Peptides; 3.10: Purification Methods; References; Chapter 3: Analogue and Conformational Studies on Peptides, Hormones and Other Biologically Active Peptides; 1: Introduction; 2: Peptide Backbone Modifications and Peptide Mimetics; 2.1: Aza, Oxazole, Oxazoline, Triazole, Triazine and Tetrazole Peptides; 2.2: [CH=CH], [Z-CF CH], [CH(OH)-CH2], [CH(OH)-CH2-NH], retro- and retro-inverso- [NHCH(CF3)], [CH2O], retro- [CONR], [CO-N(NPht)], [O-CO-N], [CO-NR-O], [CH2NH], [CO-CH2-cyclopropyl-NH], [PO2R-N], [PO2R], [NHCO]; 2.3: Rigid Amino Acid, Peptide and Turn Mimetics; 3: Cyclic Peptides; 4: Biologically Active Peptides; 4.1: Peptides Involved in Alzheimer's Disease; 4.2: Antimicrobial Peptides; 4.3: ACTH peptides; 4.4: Angiotensin II Analogues and Non-peptide Angiotensin II Receptor Ligands; 4.5: Bombesin/Neuromedin Analogues; 4.6: Bradykinin Analogues; 4.7: Cholecystokinin Analogues, Growth Hormone-Releasing Peptide and Analogues; 4.8: Integrin-Related Peptide and Non-Peptide Analogues; 4.9: LHRH and GnRH Analogues; 4.10: -MSH Analogues; 4.11: MHC Class I and II Analogues; 4.12: Neuropeptide Y (NPY) Analogues; 4.13: Opioid (Neuropeptide FF, Enkephalin, Nociceptin, Deltorphin and Dynorphin) Peptides; 4.14: Somatostatin Analogues; 4.15: Tachykinin (Substance P and Neurokinin) Analogues; 4.16: Vasopressin Analogues; 4.17: Insulins and Chemokines; 4.18: Peptide Toxins; 4.19: Miscellaneous; 5: Enzyme Inhibitors; 5.1: Aminopeptidase Inhibitors; 5.2: Calpain Inhibitors; 5.3: Carboxypeptidase Inhibitors; 5.4: Caspase Inhibitors; 5.5: Cathepsin and Other Cystein-Protease Inhibitors; 5.6: Cytomegalovirus and Rhinovirus 3C Protease Inhibitors; 5.7: Converting Enzymes and Their Inhibitors; 5.8: Elastase Inhibitors; 5.9: Farnesyltransferase Inhibitors; 5.10: HIV Protease Inhibitors; 5.11: Matrix Metalloproteinase Inhibitors; 5.12: NO-Synthase Inhibitors; 5.13: Proteasome Inhibitors; 5.14: Protein Phosphatase Inhibitors; 5.15: Renin and Other Aspartyl Proteinase Inhibitors; 5.16: Thrombin and Factor Xa Inhibitors; 5.17: Trypsin and Other Serine Protease Inhibitors; 5.18: tRNA Synthetase Inhibitors; 5.19: Miscellaneous; 6: Phage Library Leads; 7: Protein-protein Interaction Inhibitors; 7.1: SH2 and SH3 Domain Ligands; 8: Advances in Formulation/Delivery Technology; References; Chapter 4: Cyclic, Modified and Conjugated Peptides; 1: Introduction; 2: Cyclic Peptides; 2.1: General Considerations; 2.2: Cyclic Dipeptides (Dioxo or Diketo-piperazines); 2.3: Cyclotripeptides; 2.4: Cyclotetrapeptides; 2.5: Cyclopentapeptides; 2.6: Cyclohexapeptides; 2.7: Cycloheptapeptides; 2.8: Cyclooctapeptides; 2.9: Cyclononapeptides; 2.10: Cyclodecapeptides; 2.11: Higher Cyclic Peptides; 2.12: Peptides Containing Thiazole/Oxazole Rings; 2.13: Cyclodepsipeptides; 3: Modified and Conjugated Peptides; 3.1: Phosphopeptides; 3.2: O-Sulfated Peptides; 3.3: Glycopeptide Antibiotics; 3.4: Glycopeptides; 3.5: Lipopeptides; 4: Miscellaneous Structures; References; Chapter 5: Metal Complexes of Amino Acids and Peptides; 1: Introduction; 2: Amino Acid Complexes; 2.1: Synthesis and Structural Studies; 2.2: Solution Studies; 2.3: Kinetic Studies; 2.4: Synthetic, Analytical and Biomedical Applications of Amino Acid Complexes; 3: Peptide Complexes; 3.1: Synthesis and Structural Studies on Peptide Complexes; 3.2: Kinetics and Reactivity; 3.3: Solution Equilibria - Metal Ion Speciation of Peptide Complexes; 3.4: Metal Complexes of Peptides Containing Histidyl and Cysteinyl Residues; 3.5: Synthetic, Analytical and Biomedical Applications of Peptide Complexes; References

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