Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols

Author:   Erik D. Roberson
Publisher:   Humana Press Inc.
Edition:   2011
Volume:   670
ISBN:  

9781607617433


Pages:   277
Publication Date:   25 October 2010
Format:   Hardback
Availability:   In Print   Availability explained
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Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols


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Author:   Erik D. Roberson
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2011
Volume:   670
Dimensions:   Width: 17.80cm , Height: 2.50cm , Length: 25.40cm
Weight:   0.728kg
ISBN:  

9781607617433


ISBN 10:   1607617439
Pages:   277
Publication Date:   25 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Contemporary Approaches to Alzheimer’s Disease and Frontotemporal Dementia.- Preparing Synthetic A in Different Aggregation States.- Isolation of Low-n Amyloid β-Protein Oligomers from Cultured Cells, CSF, and Brain.- Detecting A*56 Oligomers in Brain Tissues.- Assessing A Aggregation State by Atomic Force Microscopy.- Measuring APP Carboxy-Terminal Fragments.- Detection of APP Intracellular Domain (AICD) in Brain Tissue.- Cell-Based Assays for Regulators of Tau Biology.- Split GFP Complementation Assay for Quantitative Measurement of Tau Aggregation In situ.- Apolipoprotein E Expression and Purification.- Aβ Toxicity in Primary Cultured Neurons.- Manipulation of Gene Expression in the Central Nervous System with Lentiviral Vectors.- Selecting a Mouse Model of Alzheimer’s Disease.- Monitoring Spatial Learning and Memory in Alzheimer’s Disease Mouse Models Using the Morris Water Maze.- Step-by-Step In Situ Hybridization Method for Localizing Gene Expression Changes in the Brain.- Real-Time Visualization of Axonal Transport in Neurons.- Quantifying Biomarkers of Cognitive Dysfunction and Neuronal Network Hyperexcitability in Mouse Models of Alzheimer’s Disease: Depletion of Calcium-Dependent Proteins and Inhibitory Hippocampal Remodeling.- Epigenetic Changes in the Brain: Measuring Global Histone Modifications.

Reviews

From the reviews: This book brings together research authorities in the field of Alzheimer's disease (AD) and frontotemporal dementia (FTD) to share their laboratory methods and protocols for molecular and model systems and outcome research in the field of neurodegenerative biomedical research. ! The audience includes all laboratory scientists interested in molecular and neuroscience research that seeks a cause and cure for these two devastating disorders. ! The book is thoughtfully written and will have the greatest appeal for those with a familiarity with laboratory research methods. (Charlene Hoffman Snyder, Doody's Review Service, February, 2011)


"From the reviews: ""This book brings together research authorities in the field of Alzheimer's disease (AD) and frontotemporal dementia (FTD) to share their laboratory methods and protocols for molecular and model systems and outcome research in the field of neurodegenerative biomedical research. ... The audience includes all laboratory scientists interested in molecular and neuroscience research that seeks a cause and cure for these two devastating disorders. ... The book is thoughtfully written and will have the greatest appeal for those with a familiarity with laboratory research methods."" (Charlene Hoffman Snyder, Doody's Review Service, February, 2011) ""This is a collection of relatively modern methodologies, focused primarily on the study of amyloid-beta processing ... . Research technicians will find the 'notes' sections particularly valuable ... . provides a nice reference for anyone interested in studying putative models of Alzheimer's disease. ... Overall, the book is well organized, well written, appropriately succinct, and exceedingly useful in those areas that are addressed, and provides a valuable reference to the basic scientist studying Alzheimer's disease."" (Rudy J. Castellani, Journal of Alzheimer's Disease, Vol. 25, 2011)"


From the reviews: This book brings together research authorities in the field of Alzheimer's disease (AD) and frontotemporal dementia (FTD) to share their laboratory methods and protocols for molecular and model systems and outcome research in the field of neurodegenerative biomedical research. ... The audience includes all laboratory scientists interested in molecular and neuroscience research that seeks a cause and cure for these two devastating disorders. ... The book is thoughtfully written and will have the greatest appeal for those with a familiarity with laboratory research methods. (Charlene Hoffman Snyder, Doody's Review Service, February, 2011) This is a collection of relatively modern methodologies, focused primarily on the study of amyloid-beta processing ... . Research technicians will find the 'notes' sections particularly valuable ... . provides a nice reference for anyone interested in studying putative models of Alzheimer's disease. ... Overall, the book is well organized, well written, appropriately succinct, and exceedingly useful in those areas that are addressed, and provides a valuable reference to the basic scientist studying Alzheimer's disease. (Rudy J. Castellani, Journal of Alzheimer's Disease, Vol. 25, 2011)


From the reviews: This book brings together research authorities in the field of Alzheimer's disease (AD) and frontotemporal dementia (FTD) to share their laboratory methods and protocols for molecular and model systems and outcome research in the field of neurodegenerative biomedical research. ! The audience includes all laboratory scientists interested in molecular and neuroscience research that seeks a cause and cure for these two devastating disorders. ! The book is thoughtfully written and will have the greatest appeal for those with a familiarity with laboratory research methods. (Charlene Hoffman Snyder, Doody's Review Service, February, 2011) This is a collection of relatively modern methodologies, focused primarily on the study of amyloid-I processing ! . Research technicians will find the 'notes' sections particularly valuable ! . provides a nice reference for anyone interested in studying putative models of Alzheimer's disease. ! Overall, the book is well organized, well written, appropriately succinct, and exceedingly useful in those areas that are addressed, and provides a valuable reference to the basic scientist studying Alzheimer's disease. (Rudy J. Castellani, Journal of Alzheimer's Disease, Vol. 25, 2011)


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