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OverviewThe subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease. This text critically summarizes what is already known about aluminium toxicity in man and attempts to offers a variety of expert opinions on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's. Full Product DetailsAuthor: C. Exley (Birchall Centre for Inorganic Chemistry and Materials Science, School of Chemistry and Physics, Keele University, Keele, Staffordshire, ST5 5BG, UK)Publisher: Elsevier Science & Technology Imprint: Elsevier Science Ltd Dimensions: Width: 15.60cm , Height: 2.60cm , Length: 23.40cm Weight: 0.960kg ISBN: 9780444508119ISBN 10: 0444508112 Pages: 452 Publication Date: 03 July 2001 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Out of Print Availability: In Print ![]() Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock. Table of ContentsPreface. Why is Research into Aluminium and Life Important? (C. Exley). Selected Papers. Aluminium-Induced Bone Disease: Implications for Alzheimer's Disease (K. Abreo). The Epidemiology of Aluminium and Alzheimer's disease (V. Rondeau, D. Commenges). Aluminium-Induced Alteration of Phosphoinositide and Calcium Signalling (W.R. Mundy, T.J. Schafer). The Interaction of Aluminium with Peptides and Proteins (T. Kiss, M. Hollósi).ReviewsMark A. Lovell, University of Kentucky, USAA review of current research that describes an association between aluminium (Al) and Alzheimer's disease (AD). A historical perspective that provides a comprehensive review of research in the area followed by an informed opinion that advances what remains to be learned about the association of Al and AD. The inclusion of a table of the main epidemiological studies of the last two decades along with design structure, diagnosis and association is particularly useful. This is a well written and, for the most part, balanced monograph describing current and past studies relating Al to the pathophysiology of AD. Attractively typeset and up-to-date this book would be a useful tool for researchers interested in chemistry and biochemistry of Al not only as it relates to neuron degeneration in AD but in other diseases as well.Journal of Alzheimer's Disease Mark A. Lovell, University of Kentucky, USA A review of current research that describes an association between aluminium (Al) and Alzheimer's disease (AD). A historical perspective that provides a comprehensive review of research in the area followed by an informed opinion that advances what remains to be learned about the association of Al and AD. The inclusion of a table of the main epidemiological studies of the last two decades along with design structure, diagnosis and association is particularly useful. This is a well written and, for the most part, balanced monograph describing current and past studies relating Al to the pathophysiology of AD. Attractively typeset and up-to-date this book would be a useful tool for researchers interested in chemistry and biochemistry of Al not only as it relates to neuron degeneration in AD but in other diseases as well. Journal of Alzheimer's Disease "from:Mark A. Lovell, University of Kentucky, USA ""A review of current research that describes an association between aluminium (Al) and Alzheimer's disease (AD). A ""historical perspective"" that provides a comprehensive review of research in the area followed by an ""informed opinion"" that advances what remains to be learned about the association of Al and AD. The inclusion of a table of the main epidemiological studies of the last two decades along with design structure, diagnosis and association is particularly useful. This is a well written and, for the most part, balanced monograph describing current and past studies relating Al to the pathophysiology of AD. Attractively typeset and up-to-date this book would be a useful tool for researchers interested in chemistry and biochemistry of Al not only as it relates to neuron degeneration in AD but in other diseases as well."" --Journal of Alzheimer's Disease" Author InformationTab Content 6Author Website:Countries AvailableAll regions |