Overview

The international cosmetic industry is a highly self-regulated industry that provides quality products with a remarkable absence of toxicity. Specific European Union directives raise the need for quality in vitro methods to yet a new level. These directives will force new practices for safety evaluation of personal care products throughout the world in just a few years.Alternative Methodologies for the Safety Evaluation of Chemicals in the Cosmetic Industry presents a categorization and collection of information available for the evaluation of safety using in vitro techniques. It offers a comprehensive and complete look at the entire field. In doing so, the author provides the foundation for the next phase of significant growth for this discipline.Readers will be able to find information easily throughout the book. The author uses outlines and tables to provide details in a ready format. He puts his unique expertise and insight to paper and offers a valuable and comprehensive look at the field.T he book begins with an excellent history of the approach of the European Union. Because of Loprieno's intimate knowledge of the subject, the reader receives a solid understanding of the developments that resulted in legislation. Chapters are filled with important quotes, individual methods, how various aspects of the field were developed, and important crossroads in research. The book ends with an in-depth look at the Galileo Data Base.Alternative Methodologies for the Safety Evaluation of Chemicals in the Cosmetic Industry is extremely useful, not only now, but also as more advanced and significant developments occur during the next decade. It is a must-have resource for anyone interested in this field.

Full Product Details

Author:   Nicola Loprieno
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 17.80cm , Height: 2.00cm , Length: 25.40cm
Weight:   0.703kg
ISBN:  

9780849385469

ISBN 10:   0849385466
Pages:   272
Publication Date:   01 August 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Introduction Legislative Basis Cosmetic Ingredients The Role of Toxicology Animal Toxicity Studies Acute Toxicity Studies Dermal Irritation Studies Ocular Toxicity Studies Subacute, Subchronic, and Chronic Studies Carcinogenicity Studies Teratogenicity and Reproduction Toxicity Studies Toxicokinetic Studies Skin Absorption Mutagenicity Studies Animals Needed for Safety Evalution of a Cosmetic Ingredient In Vivo Toxicity Testing Guidelines Alternative Methodologies to Animal Testing Acute Toxicity Dermal Irritation Eye Irritation Structure-Activity Relationship Studies Teratogenicity Genotoxicity and Carcinogenicity Guidelines for In Vitro Toxicity Assays Future Developments Alternative Methodologies: State of the Art Methodologies Standardization Methodology Specificity Methodology Predictivity Alternative Methods: Perspectives In Vitro Toxicity Database Introduction The Structure of the Galileo Data Bank Use of GDB Cosmetic Ingredients References Appendix A: Acronyms Appendix B: Cell Lines Reported in the Methods Index

Reviews

The quantity and quality of information provided in the pages of this book is truly remarkable. The tables, the outlines, the lists, and the bibliography are magnificently comprehensive and complete. Professor Loprieno has written an important work that is exceedingly comprehensive, detailed and remarkably accurate. This volume is a major contribution to the field. - Alan M. Goldberg Director, Center for Alternatives to Animal Testing, Johns Hopkins University

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