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Author:   Dario Doller (Lundbeck Research, USA) ,  David Rotella ,  David Thurston ,  Jesus Giraldo
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 56
Dimensions:   Width: 15.60cm , Height: 3.00cm , Length: 23.40cm
Weight:   0.838kg
ISBN:  

9781782624592

ISBN 10:   1782624597
Pages:   437
Publication Date:   24 November 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

"Modulation of Biological Targets: Why Use Allosteric Ligands?; Identifying and Quantifying Allosteric Drug Function; Targeting Catalytic and Non-catalytic Functions of Protein Kinases; Molecular Biology Techniques Applied to GPCR Allosteric and Biased Ligands; Examining Allosterism in a Dimeric GPCR Context; A Unifying Approach to the Duality of ""Energetic"" Versus ""Conformational"" Formulations of Allosteric Coupling: Mechanistic Implications on GPCR Allostery; mGluR2 Positive Allosteric Modulators; Muscarinic Receptors Allosteric Modulation; Positive Allosteric Modulators of Opioid Receptors; mGluR7 allostery: up and down modulation; Allosteric Modulators of Adenosine, P2Y and P2X Receptors; Positive Allosteric Modulators of G Protein-Coupled Receptors that Act via Covalent Mechanisms of Action; mGluR4 PET ligands as enablers of target biology understanding; Mechanism of action of a GluN2C- and GluN2D-selective NMDA receptor positive allosteric modulator; Development of AMPA Receptor Modulators as Cognition Enhancers; Allosteric modulation of the neuronal nicotinic acetylcholine receptor; Allosteric Binding in the Serotonin Transporter – Pharmacology, Structure, Function and Potential Use as a Novel Drug Target; Allosteric Inhibition of Abl Kinase; Allosteric Modulators of Heat Shock Protein 90 (HSP90); A look forward;"

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