Overview

A bridge for industrial and academic collaborations, this book overviews the concepts and therapeutic application of allosteric modulation to control protein function explaining why it has gained strong momentum in drug discovery, technologies and methodologies to discover allosteric modulators, and allosteric modulator compounds. Collects into one single resource the details on allosteric modulation of key drug targets, making for an encyclopedic coverage from basics to drug discovery applications Describes methods to detect and analyze allosterism Lets readers compare how allosteric modulators function and used across different platforms Includes the major drug target classes with demonstrated allosteric modulation Features a companion website with color images and protocols that readers can access

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9781118568576

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Author Information

Huailing Zhong, PhD, is president of U-Pharm Laboratories LLC, based in New Jersey. He has several scientific publications and has given multiple invited speeches on the signaling mechanisms as well as therapeutic discoveries within GPCRs, transporters and other targets. Lauren T. May, PhD, is a postdoctoral fellow of the National Health and Medical Research Council of Australia (NHMRC) based within the Drug Discovery Biology Laboratory, Monash University, Australia. She has numerous publications in journals and books and her research has been presented at 27 scientific conferences.

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