Overview

"Building on the existing titles in the ""Airways Smooth Muscle"" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry."

Full Product Details

Author:   David Raeburn ,  Mark A. Giembycz
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Edition:   Softcover reprint of the original 1st ed. 1994
Dimensions:   Width: 17.00cm , Height: 1.90cm , Length: 24.40cm
Weight:   0.711kg
ISBN:  

9783034876834

ISBN 10:   3034876831
Pages:   352
Publication Date:   12 September 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Smooth Muscle Myosin: Molecule Conformation, Filament Assembly and Associated Regulatory Enzymes.- 2. Actin and Thin-Filament-Associated Proteins in Smooth Muscle.- 3. Current Concepts on Mechanisms of Force Generation in Airways Smooth Muscle.- 4. Phosphoinositidase C, Inositol Polyphosphates and Force Generation of Airways Smooth Muscle.- 5. The Intracellular Calcium Store in Airways Smooth Muscle.- 6. Current Concepts on Mechanisms of Force Maintenance in Airways Smooth Muscle.- 7. Diglyceride, Protein Kinase C and Force Maintenance of Airways Smooth Muscle.- 8. Sources of Activator Calcium for Force Generation and Maintenance of Airways Smooth Muscle.- 9. G-Proteins in Airways Smooth Muscle.- 10. Cyclic AMP and the Control of Airways Smooth Muscle Tone.- 11. Myosin Dephosphorylation as a Mechanism of Relaxation of Airways Smooth Muscle.- 12. Cyclic GMP and the Control of Airways Smooth Muscle Tone.- 13. Cyclic Nucleotide Phosphodiesterases in Airways Smooth Muscle.- 14. Modulation of Agonist-Stimulated Phosphoinositide Turnover in Airways Smooth Muscle by Cyclic Nucleotide-Dependent and Independent Mechanisms.- 15. Airways Smooth Muscle Cells in Culture.

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