Overview

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumours, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). Providing a complete overview of the clinical course of HIV-1 infection, this text describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the laboratory markers being used in 2000 that allow for monitoring of the clinical course of infection.

Full Product Details

Author:   H. Schuitemaker ,  Frank Miedema
Publisher:   Springer
Imprint:   Springer
Edition:   2000 ed.
Volume:   28
Dimensions:   Width: 17.00cm , Height: 1.70cm , Length: 24.40cm
Weight:   1.320kg
ISBN:  

9780792361961

ISBN 10:   0792361962
Pages:   284
Publication Date:   31 March 2000
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Aids Pathogenesis: Table of Contents.- 1 HIV-1 transmission.- 2 Primary HIV infection.- 3 Biological variability of HIV-1.- 4 T-cell dynamics and renewal in HIV-1 infection.- 5 Long-term non-progressive HIV infection.- 6 Cytotoxic T lymphocytes in HIV-1 infection.- 7 Mechanisms and in-vivo significance of HIV-1 neutralisation.- 8 Suppression of primate immunodeficiency lentiretroviruses CD8+ T-cell-derived soluble factors.- 9 Opportunistic infections.- 10 — AIDS-related non-Hodgkin’s lymphomas.- — Pathogenesis of Kaposi’s sarcoma.- 11 AIDS dementia complex.- 12 Anti-retroviral therapy and resistance to anti-retroviral drugs.- 13 Prognostic markers and immunological reconstistution during HIV-1 infection.- 14 HIV-viral load.- 15 — The SCID-hu mouse: an in-vivo model for HIV-1 infection in humans.- — Non-human primate models for HIV-1 infection.

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