Overview

Although thousands of articles and hundreds of books on aging have been published, only a small percentage of this material has dealt with anatomy, particularly at the fine­ structural level. It was with this in mind that Aging and Cell Structure was conceived. Volume 1 of Aging and Cell Structure was published in 1981 and represented a current compilation of information, concentrating at the electron microscopic level, on morphological changes which occur in cells and tissues as they age. The present volume completes the two-volume set. While Volume 1 highlighted structural changes occurring in the aging nervous system, Volume 2 centers its efforts on studies of in vitro aging. Chapters on other subjects are included as well. These include age-related changes seen in neuromuscular junctions, oral tissues, and the pancreas. Although these two volumes represent a very small part of the published infor­ mation on experimental gerontology, their approach is rather unique because they focus on anatomy, perhaps the most basic of all the biomedical sciences. Because many dif­ ferent tissue types are examined, we begin to see recurrent, definitive patterns in the aging cell which may not be fully apparent from studies taking one cell type at a time. This becomes even more evident in the present volume where changes seen in popula­ tions of cells grown in culture-isolated from hormones or nervous impulses from other body areas-are found to be similar to those changes found in vivo.

Full Product Details

Author:   John E. Johnson
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1984
Dimensions:   Width: 17.80cm , Height: 1.30cm , Length: 25.40cm
Weight:   0.463kg
ISBN:  

9781468446098

ISBN 10:   1468446096
Pages:   223
Publication Date:   08 March 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. The Aging Cell Surface: Structural and Biochemical Alterations Associated with Progressive Subcultivation of Human Diploid Fibroblasts.- 1. Introduction.- 2. Development of Heterogeneity in Cultures.- 3. Changes in the Cell Membrane.- 4. Changes in the External Cell Surface.- 5. The Cytoskeleton.- 6. Summary and Conclusions.- References.- 2. In Vivo and in Vitro Comparisons of Age-Related Fine Structural Changes in Cell Components.- 1. Introduction.- 2. The Cell Nucleus.- 3. The Cell Cytoplasm.- 4. The Cell Surface.- 5. Conclusion.- References.- 3. New Concepts in Regulation of the Lifespan of Human Diploid Fibroblasts in Vitro.- 1. Introduction.- 2. The Decline in Proliferative Capacity of Human Diploid Fibroblasts in Culture.- 3. Morphological Changes in HDF during the in Vitro Lifespan.- 4. Kinetic Compartments of Human Diploid Fibroblasts in Vitro.- 5. Genetic Regulation of the Loss of Proliferative Capacity.- 6. Conclusions and Future Directions.- References.- 4. Aging at the Neuromuscular Junction.- 1. Introduction.- 2. Physiological Changes.- 4. Morphology.- 5. Summary and Conclusions.- References.- 5. Human Oral Tissues as a Model for the Study of Cellular Age Changes by Light Microscopy.- 1. Introduction.- 2. Tooth and Periodontium.- 3. Maxilla and Mandible.- 4. Tongue.- 5. Salivary Glands.- 6. Summary.- References.- 6. Morphological Changes in the Aging Mammalian Pancreas.- 1. Introduction.- 2. Age-Related Morphological Changes in the Exocrine Pancreas.- 3. Age-Related Morphological Changes in the Endocrine Pancreas.- References.

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