Overview

This volume highlights recent advances in the research of neurodegenerative processes and cell death. Also the role of inflammation in neurodegenerative processes is elucidated. A respectable number of articles deals with neuroprotective/neuroregenerative strategies. Although most of this work is preclinical, there is also first evidence from clinical studies that neuroprotection should be possible in neurodegenerative disorders such as Parkinson's disease, amyotropic lateral sclerosis, Huntington's Chorea and eventually also Alzheimer's disease. Top scientists and international opinion leaders discussed and lectured at the 8th International Winter Conference on Neurodegeneration (IWCN) in Tegernsee, Bavaria, Germany, from February 9-13, 2000. And they have put together a valuable, comprehensive and timely piece of work that reviews all the above-mentioned problems and tries to evaluate therapeutic strategies of the future.

Full Product Details

Author:   P. Riederer ,  D.B. Calne ,  R. Horowski ,  Y. Mizuno
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Edition:   2000 ed.
Weight:   1.443kg
ISBN:  

9783211835388

ISBN 10:   3211835385
Pages:   421
Publication Date:   13 December 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

The L-DOPA story revisited. Further surprises to be expected?.- The enigma of cell death in neurodegenerative disorders.- Impaired iron homeostasis in Parkinson’s disease.- The molecular mechanism of dopamine-induced apoptosis: identification and charac te rization of genes that med iate dopamine toxicity.- Glyce raldehyde-3-phosp hate dehydrogenase in neurodegenerat ion and apoptosis signaling.- Import ance of familial Parkinson’s disease and parkinsonism to the understand - ing of nigraI degener at ion in sporadic Parkinson’s disease.- cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6 hydroxydopamine models: implications for idiopathic Parkinson’s disease.- Moni toring neurop rotection and restorative therapies in Parkinson’s disease with PET.- Common properties for prop argylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of ( 2212; )deprenyl.- TV3326, a novel neuro protective dru g with cholinesterase and monoamine oxidase inhibito ry activities for the treatm ent of Alzheimer’s disease.- Neurotoxins induce apoptosis in dopamine neurons: prot ection bei N-propargylamine- l(R)- and (5)-aminoi ndan, rasagi line and TV1022.- Homocysteine and alcoholism.- Neur orescuing effects of the GAPDH ligand CGP 34668.- The neuroprotective effects of CGP 34668 in the best in vivo model of Parkinson’s disease, the bilaterally MPTP-treated rhesus monke.- Neurotrophic effects of central nicotinic receptor activation.- Regulation of neuronal cell death and differentiation by NGF and IAP family members.- Insulin-like growth factor- 1 (IGF-1): a neuroprotective trophic factor acting via the Aktinase pathway.-GDF-15/MIC-1 a novel member of the TGF-? superfamily.- Changes in cytokines and neurotrophins in Parkinson’s disease.- Psychiatric complications in Parkinson’s disease.- Dementia with Lewy bodies: prevalance, clinical spectrum and natural history.- Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits.- Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.- The serotonin transporter in Alzheimer’s and Parkinson’s disease.- Immunopathogenic and clinical relevance of antibodies against myelin oligodendrocyte glycoprotein (MOG) in Multiple Sclerosis.- Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis.- Glutamate excitotoxicity — a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?.- Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions