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OverviewThis inaugural issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology. Publishing on an annual basis, the volume will be divided into 7 sections: Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid tumors, and Identity/HLA. Led by Dr. Gregory Tsongalis of Dartmouth University, a team of experienced pathologists from institutions across the country oversee annual topic and expert author selection. Topics discussed in this volume include, but are not limited to: whole genome sequencing in critically ill children, bioinformatics in clinical genomic sequencing, comprehensive monitoring of patients with chronic myeloid leukemia, genetic biomarkers in the biology and clinical workup of chronic lymphocytic leukemia, metagenomics in infectious disease, point of care molecular testing, pharmacogenomics in oncology, clinical uses of panel testing vs. single gene testing, large scale data sharing initiatives in genomic oncology, clinical NGS assays for solid tumors emerging concepts in liquid biopsy the cell line and tissue misidentification problem, and cell line detective work. Full Product DetailsAuthor: Gregory J. Tsongalis, PhD, HCLD, CC, FNACBPublisher: Elsevier - Health Sciences Division Imprint: Elsevier - Health Sciences Division Volume: 1-1 ISBN: 9780323639651ISBN 10: 0323639658 Publication Date: 25 October 2018 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsGENETICS 1. Coming Up to Speed on Whole Genome Sequencing in Critically Ill Children 2. Bioinformatics in Clinical Genomic Sequencing 3. The clinical application of RNA sequencing in genetic diagnosis of Mendelian disorders HEMATOPATHOLOGY 4. The clinical and laboratory features of clonal hematopoiesis of indeterminate potential (CHIP) 5. Comprehensive Monitoring of Patients with Chronic Myeloid Leukemia 6. Genomic Biomarkers in Pathogenesis and Clinical Care of Chronic Lymphocytic Leukemia (CLL) INFECTIOUS DISEASE 7. Molecular Monitoring of Viral Infections 8. The Current State of Metagenomics in Infectious Disease 9. Replacement of Culture with Molecular Testing for Diagnosis Infectious Diseases 10. Syndromic and point of care molecular testing PHARMACOGENOMICS 11. Applications of Pharmacogenomics in Oncology 12. Building Evidence for Clinical Use of Pharmacogenomics and Reimbursement for Testing INFORMATICS 13. Large scale data sharing initiatives in genomic oncology 14. Advances in Next Generation Sequencing Bioinformatics for Clinical Diagnostics: Taking Precision Oncology to the Next Level SOLID TUMORS 15. Clinical NGS Assays for Solid Tumors: Current Practices, Technological Advances and Challenges in Clinical Practice 16. Emerging Concepts in Liquid Biopsy 17. Therapy Implications of DNA Mismatch Repair Deficiency, Microsatellite Instability, and Tumor Mutation Burden IDENTITY/HLA 18. Tackling the Human Cell Line and Tissue Misidentification Problem is Needed for Reproducible Biomedical Research 19. Cell Line Detective Work: Basic Principles and Molecular Applications 20. Challenges and Advances in the Development of Cell Lines and Xenografts 21. Historical and Current Methods for Detecting Inter- and Intra-species Cell Mixtures and Thereby Assuring Cell Line PurityReviewsAuthor InformationGregory Tsongalis, Ph.D., H.C.L.D., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College's Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master's Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards. Tab Content 6Author Website:Countries AvailableAll regions |
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