Overview

This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.

Full Product Details

Author:   Eric J. Toone (Duke University, Durham, NC)
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Edition:   Volume 78
Volume:   78
Dimensions:   Width: 16.30cm , Height: 3.60cm , Length: 23.60cm
Weight:   0.943kg
ISBN:  

9781118014288

ISBN 10:   1118014286
Pages:   568
Publication Date:   16 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Contributors vii Preface ix Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1 Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin Physiopathological Roles of Human Transglutaminase 2 47 Vittorio Gentile Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97 Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161 Soo-Youl Kim Transglutaminase 2 At the Crossroads between Cell Death and Survival 197 Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo Tissue Transglutaminase and Its Role in Human Cancer Progression 247 Bo Li, Richard A. Cerione, and Marc Antonyak Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295 Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo Fesus Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347 Zoltan Nemes Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385 Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti Irreversible Inhibitors of Tissue Transglutaminase 415 Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449 Marıa A. Pajares and George D. Markham Index 523

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Author Information

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

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