Overview

The results of a six-year study on the pathogenesis of posttraumatic adult respiratory distress syndrome (ARDS) are presented in this volume. The study investigates important mediator and cell system changes and functions with close reference to clinical findings. It becomes apparent in this study that posttraumatic lung failure is one aspect of generalized organ dysfunction. Definite organ damage is here demonstrated to occur initially after trauma and is not related to a posttraumatic septic reaction after several days. In addition to the clinical study, data on pathobiochemical changes and immune response for the same time intervals are recorded. By comparing the data and pathophysiological interactions, it is hoped that new ways of treating posttraumatic organ damage can be developed.

Full Product Details

Author:   J.A. Sturm
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.555kg
ISBN:  

9783540521808

ISBN 10:   3540521801
Pages:   347
Publication Date:   07 May 1991
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

I Clinical Aspects.- Study Protocol.- Extravascular Lung Water: Clinical Methodology.- Bronchoalveolar Lavage.- Morphometric Description of the Study Population.- Development of a Linear Scoring System.- Clinical Definition of ARDS An Index Based on Bedside-Derived Parameters.- Treatment and Clinical Course.- Progressive Organ Failure.- II Activation of Humeral Cascade Systems.- Adult Respiratory Distress Syndrome and Complement: Significance of C3a in Diagnosis and Prognosis.- Differences in Activation of Coagulation and Fibrinolysis After Polytrauma with Respect to the Development of Adult Respiratory Distress Syndrome.- III Activation of Cellular Systems.- Nonspecific Immune System, Plasma Proteins and Characteristics of the Erythrocyte Insulin Receptor.- Morphological and Functional Changes of Alveolar Cells.- Functional Changes in Polymorphonuclear Leukocyte Function Following Severe Polytraumatization.- Changes in Reticuloendothelial Capacity Associated with Liver Dysfunction in Multiple Trauma.- CD3 +, CD4+, CD8+ and B Lymphocyte Numbers in Blood and Bronchoalveolar Lavage Fluid from Trauma Patients with and without ARDS.- IV Activation of Inflammatory Cells.- Role of Leukotrienes in the Pathophysiology of ARDS After Polytrauma.- Specific Proteins of Inflammatory Cells and ?1- Proteinase Inhibitor in Alveolar Epithelial Lining Fluid of Polytraumatized Patients: Do They Indicate Posttraumatic Lung Failure?.- V Endothelial and Epithelial Mechanisms of Injury.- Plasma and Bronchoalveolar Lavage Fluid Proteins as Markers of Increased Lung Permeability in ARDS as a Result of Multiple Trauma.- Lung Capillary Leak After Severe Trauma: A Prospective Clinical Study.- Alveolar Surfactant Function in Severely Injured Patients.- Adult Respiratory Distress Syndrome as aManifestation of a General Permeability Defect.- Early and Late Ultrastructural Changes in the Lungs of Patients Suffering from Severe Polytrauma.- VI Experimental Studies.- Simultaneous Measurement of Endothelial Cell Damage, Elastase Release, and Chemiluminescence Response During Interaction Between Polymorphonuclear Leukocytes and Endothelial Cells.- Influence of Short- and Long-Term Endotoxin Administration on the Phagocytic Functions of Polymorphonuclear Leukocytes and Reticuloendothelial System in a Sheep Model.- The Three-Compartment Model in Sheep: The Effect of Recurrent Endotoxemia on Endothelial and Epithelial Permeability in the Lung.- Bacterial Toxins and Terminal Complement Complex: Significance for Lung Microvascular Injury.

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