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Author:   Myron K. Jacobson ,  Elaine L. Jacobson ,  Elaine L. Jacobson ,  Elaine L. Jacobson
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1989 ed.
Weight:   1.060kg
ISBN:  

9780387970875

ISBN 10:   0387970878
Pages:   527
Publication Date:   18 September 1989
Audience:   College/higher education ,  General/trade ,  Postgraduate, Research & Scholarly ,  General
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

One: Enzymology of ADP-Ribosylation.- Amino Acid-Specific ADP-Ribosylation: Purification and Properties of an Erythrocyte ADP-Ribosylarginine Hydrolase.- ADP-Ribosyltransferase and Endogenous Acceptor Proteins in Animal Muscle Tissues: ADP-Ribosylation of Ca2+-Dependent ATPase in Rabbit Skeletal Muscle Sarcoplasmic Reticulum and the Effect of Basic Peptides.- Endogenous ADP-Ribosylation of Proteins at Cysteine Residues.- Reversible ADP-Ribosylation of Dinitrogenase Reductase from Rhodospirillum rubrum Regulates the Activity of the Enzyme In Vivo and In Vitro.- Phospho ADP-Ribosylation and Phospho Adenylylation of Proteins.- ADP-Ribosyl Transferase of Mitochondria and of Ribonucleoprotein Particles Containing Silent Messenger RNA.- In Vitro Evidence for Poly(ADP-Ribosyl)ation of DNA Polymerase ?- Primase and Phosphorylation of Poly(ADP-Ribose) Synthetase by Protein Kinase C.- Poly(ADP-Ribose) Glycohydrolase and ADP-Ribosyl Group Turnover.- In Vitro ADP-Ribosylation Utilizing 2’Deoxy-NAD+ as a Substrate.- Reconstitution of an In Vitro Poly(ADP-Ribose) Turnover System.- Effect of Selected Octadeoxyribonucleotides and 6-Amino-1,2 Benzopyroneon Poly(ADP Ribose) Transferase Activity.- Two Tests of the Direction of Elongation of Poly (ADP-ribose): Residues are Added at the Polymerase-Proximal Terminus.- Biosynthesis and Degradation of Poly(ADP-Ribose) Synthetase.- Monoclonal Antibodies Against Poly(ADP-Ribose) Polymerase: Epitope Mapping, Inhibition of Activity and Interspecies Immunoreactivity.- Poly(ADP-Ribose) Polymerase: Determination of Content From TCA-Precipitated Cells, Existence of Species-Specific Isoforms and Changes During the Growth Cycle.- ADP-Ribosylation in Mitochondria: Enzymatic and Non Enzymatic Reactions.- Localization of the Zinc-Binding Sites in the DNA-Binding Domain of the Bovine Poly(ADP-Ribose) Polymerase.- Heterogeneity of Polyclonal Antisera to ADP-Ribose and Their Use as Probes for ADP-Ribosylation in Human Tumor Cells.- ADP-Ribosylating Activity in Sulfolobus solfataricus.- Alteration of Poly(ADP-Ribose) Metabolism By Ethanol: Kinetic Mechanism of Action.- The Effect of Benzamides on the Activity of Nuclear ADP-Ribosyl Transferase and the Accumulation of Poly(ADP-Ribose) In Vivo.- Carba-Nicotinamide Adenine Dinucleotide: Synthesis and Enzymological Application of a Novel Inhibitor of ADP-Ribosyl Transfer.- Purification and Properties of Two Forms of Poly(ADP-Ribose) Glycohydrolase.- Poly(ADP-Ribosyl)ation in Free Cytoplasmic mRNA-Protein Complexes.- New Inhibitors of Poly(ADP-Ribose) Synthetase.- Monoclonal Antibodies to Human Placental Poly(ADP-Ribose) Synthetase.- Characterization of the Human Autoantibody Response to Poly(ADP-Ribose) Polymerase.- In Vivo Automodification of Poly(ADP-Ribose) Polymerase and DNA Repair.- Two: ADP-Ribosylation and Chromatin Function.- ADP-Ribosylation and Chromatin Function.- Modulation of Chromatin Structure by Poly (ADP-Ribosyl)ation.- Automodified Poly(ADP-Ribose) Synthetase Detected in Rat Liver Cells is Selectively Attached to a Nuclear Matrix-Like Structure.- Studies on the Nuclear Distribution of ADP-Ribose Polymers.- A Proposed Molecular Mechanism of Nucleosome Unfolding. Effect of Poly(ADP-Ribose) on DNA-Histone H4 Interaction.- On the Nature of the Interaction Between Poly(ADP-Ribose) Polymerase and DNA.- Inhibition of ADP-Ribosyl Transferase Activity Blocks the Stable Integration of Transfected DNA into the Mammalian Cell Genome.- Role of Poly(ADP-ribose) Polymerase in Ribosomal RNA Gene Transcription.- ADP-Ribosylation of HeLa Chromosomal and Nuclear Proteins: Response to DNA Damage Caused by Chemical Mutagens.- Poly(ADP-Ribose) Polymerase: DNA Complexes Visualized as Looped Structures by Electron Microscopy.- Poly(ADP-Ribose) May Signal Changing Metabolic Conditions to the Chromatin of Mammalian Cells.- Uncoupling of DNA Excision Repair and Chromatin Rearrangements in Poly(ADP-Ribose)-Depleted Cells.- Highly Sensitive Method for Immunohistochemical Detection of Poly(ADP-Ribose) in Various Animal Species.- Three: Carcinogenesis and Differentiation.- Poly(ADP-Ribosyl)ation of Nuclear Proteins By Oxidant Tumor Promoters.- The Cytogenetic Effects of an Inhibition of Poly(ADP- Ribose) Polymerase.- Effect of 3-Aminobenzamide on the Induction of ?- Glutamyltrans-peptidase Positive Foci in the Liver of Rats Treated with Various Chemical Carcinogens.- A Role of Poly(ADP-Ribosyl)ation in Carcinogen-Inducible Transient DNA Amplification.- Arrest of Tumor Growth by DNA-Site Inhibitors of Adenosine Diphosphoribose Transferase.- Inhibition of SV40 Replication In Vitro by Poly(ADP-Ribosyl)ated Diadenosine Tetraphosphate.- Killing and Mutation of Density Inhibited V-79 Cells as Affected by Inhibition of Poly(ADP-Ribose) Synthesis.- Influence of Benzamide and Nalidixic Acid on the Killing and Mutation Induced in V-79 cells by N-Methyl-N’-Nitro-N-Nitrosoguanidine.- Loss of Poly(ADP-Ribose) Transferase Activity in Liver of Rats Treated with 2-Aeetylaminofluorene.- V-79 Cell Variants Deficient in Poly(ADP-Ribose) Polymerase.- Cytotoxicity of TPA-Stimulated Granulocytes and Inhibitors of ADP-Ribosylation.- 3-Aminobenzamide Enhances X-Ray Induction of Chromosome Aberrations in Down Syndrome Lymphocytes.- 3-Methoxybenzamide, A Possible Initiator for DMBA-Induced Carcinogenesis.- Synergistic Induction of Sister Chromatid Exchanges and Cell Division Delays in Ehrlich Ascites Tumor Cells Treated with Cytoxan and Caffeine In Vivo.- Inhibition of Poly(ADP-Ribosyl)ation and Sister Chromatid Exchange Induction.- Differential Effect of Benzamide on Repair-Deficient and Proficient Strains of L5178Y Lymphoblasts Exposed to UVC or X-Radiations.- Nicotinamide Deficiency and Sister Chromatid Exchanges.- ADP-Ribosyl Transferase in the Differentiation of Protozoa and Embryonic Mouse Thymus.- ADP-Ribosylation of Leukemia Cell Membrane Proteins Correlates with Granulocyte Colony-Stimulating Factor Dependent Differentiation.- Poly(ADP-Ribose) Transferase in Lizard Oviduct.- DNA Damage Does Not Induce Lethal Depletion of NAD During Chicken Spermatogenesis.- Divergence of Poly(ADP-Ribose) Polymerase Activity, Poly(ADP- Ribose) Levels and the Effect of Polymerase Inhibitors in Differentiating 3T3-L1 Preadipocytes.- Differences in DNA Supercoiling and ADP-Ribosylation During Granulocytic and Monocytic Differentiation.- Niacin Analogs that Induce Differentiation of Friend Erythroleukemia Cells are Able to Cause DNA Hypomethylation.- In Vivo Poly(ADP-Ríbose) Levels in Carcinogen Treated Human Promyelocytic Leukemia Cells.- Activation-Inactivation of PoIy(ADP-Ribose) Transferase of Mammalian Cells Exposed to DNA Damaging Agents.- Four: NAD Metabolism and Chemotherapy.- Aspects of NAD Metabolism in Prokaryotes and Eukaryotes.- An Approach to the Selective Targeting of NAD Consuming Reactions in Cultured Mammalian Cells.- Pyridine Nucleotide Metabolism as a Target for Cancer Chemotherapy.- Pivotal Role of PoIy(ADP-Ribose) Polymerase Activation in the Pathogenesis of Immunodeficiency and in the Therapy of Chronic Lymphocytic Leukemia.- Active Transport of Nicotinamide and the Adenine Moiety of NAD by Metabolically Controlled NAD Catabolism.- The Effect of Extracellular Calcium on NAD Metabolism in Human Diploid Cells.- Reduced Tumor Progression In Vivo by an Inhibitor of Poly (ADP-Ribose) Synthetase (3-Aminobenzamide) in Combination with X-Rays or Cytostatic Drug DTIC.- Cytotoxic Effects of 3-Aminobenzamide in CHO-K1 Cells Treated with Purine Antimetabolites.- Hyperthermia and Poly (ADP-Ribose) Metabolism.- Comparison of Low Dose Nicotinamide Versus Benzamide as Radiosensitizers in a C3H Mammary Carcinoma.- Viral Hepatitis in Mice and ADP-Ribose Metabolism.- Five: ADP-Ribosylation and Signal Transduction.- GTP-Binding Proteins, Substrates of Pertussis Toxin-Catalyzed ADP-Ribosylation, as Mediators of Receptor-Coupled Signal Transduction.- Clostridium botulinum Exoenzyme C3 ADP-Ribosylates and Functionally Modifies p21.bot in PC12 Cells Without Affecting Neurosecretion.- ADP-Ribosylation of Human c-Ha-ras Protein by Hen Liver ADP-Ribosyl Transferase.- Mono(ADP-Ribosylation) in Rat Liver Mitochondria.- Botulinum Neurotoxins ADP-Ribosylate A Novel GTP-Binding Protein (Gb).- C3: A Novel Botulinum ADP-Ribosyltransferase Modifies a Putative 21 kDA G-Protein.- Stimulation of Choleragen Enzymatic Activities by GTP and a Membrane Protein from Bovine Brain.- Activation of the NAD Glycohydrolase, NAD:Agmatine and NAD:Gs? ADP-Ribosyltransferase and Auto-ADP-Ribosylation Activities of Choleragen by Guanyl Nucleotide and Soluble Proteins Purified from Bovine Brain.- Six: Molecular Genetic Approaches to ADP- Ribosylation.- Active Sites and Homology of Diphtheria Toxin and Pseudomonas aeruginosa Exotoxin A.- The Cloning of the cDNA and Gene for Human Poly(ADP-Ribose) Polymerase: Status on the Biological Function(s) Using Recombinant Probes.- Adenosine Diphosphate Ribosylation of Elongation Factor-2 as a Therapeutic Target: Genetic Construction and Selective Action of a Diphtheria Toxin-Related Interleukin-2 Fusion Protein.- Molecular Structure of Poly(ADP-Ribose) Synthetase.- The Biological Function(s) of the Poly(ADP-Ribose) Polymerase as Observed by Transient Expression of the cDNA and Transcriptional Regulation of the Gene.- Rapid Isolation of ADP-Ribosyl Transferase by Specific Precipitation and Partial Sequencing of its DNA-Binding Domain.- Sequence Analysis of the DNA Associated with Poly(ADP-Ribose) Polymerase Molecules.- Molecular Cloning of cDNA for Human Placental PoIy(ADP-Ribose) Polymerase and Decreased Expression of its Gene during Retinoic Acid-Induced Granulocytic Differentiation of HL-60 Cells.- Isolation of a cDNA Clone Encoding Bovine Poly(ADP-Ribose) Synthetase by Immunological Screening of a cDNA Expression Library and its Application as a Probe.- Radiation Sensitivity of Human Cells and the Poly(ADP-Ribose) Polymerase Gene.

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