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Author:   Tobias Langenhan ,  Torsten Schöneberg
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Volume:   234
Weight:   7.086kg
ISBN:  

9783319823751

ISBN 10:   3319823752
Pages:   403
Publication Date:   23 June 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

PART I. Molecular and Pharmacological Properties of Adhesion GPCRs:-Classification, Nomenclature and Structural Aspects of Adhesion GPCRs.- 7TM Domain Structure of Adhesion GPCRs.- Understanding the Structural Basis of Adhesion GPCR Functions.-Control of Adhesion GPCR Function Through Proteolytic Processing.-Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs.- Versatile Signaling Activity of Adhesion GPCRs.-  Adhesion GPCR-Related Protein Networks.-The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans.- PART II: Adhesion GPCRs as Pharmakotargets in Organ Function and Development.- Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors.- Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration.- Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.-Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs.- Adhesion GPCR Function in Pulmonary Development and Disease.-Adhesion GPCRs as Modulators of Immune Cell Function.-Heart Development, Angiogenesis, and Blood-Brain Barrier Function is Modulated by Adhesion GPCRs.-Adhesion GPCRs in Tumorigenesis.

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