Overview
Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry – agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors – biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson’s disease therapy, and much more.
Full Product Details
Author: Jiang-Fan Chen (Associate Professor, Departments of Neurology and Pharmacology and Experimental Therapeutics, Boston University Medical Center, MA, USA) ,
Akihisa Mori (SNLD Ltd., Japan)
Publisher: Elsevier Science Publishing Co Inc
Imprint: Academic Press Inc
Weight: 0.450kg
ISBN: 9780443186677
ISBN 10: 0443186677
Pages: 324
Publication Date: 19 September 2023
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: Manufactured on demand
We will order this item for you from a manufactured on demand supplier.
Author Information
Jiang-Fan Chen, MD, PhD, is an Associate Professor in the Boston University Medical Campus--Departments of Neurology and Pharmacology and Experimental Therapeutics. Dr. Chen’s research focuses on the neurobiology of adenosine and the A2A adenosine receptor and the role they may play in the development and treatment of neuropsychiatric disorders. Dr. Chen has developed an A2A receptor knockout mouse model and couples this genetic approach with pharmacological manipulation to explore the pathophysiological role of A2A receptors in animal and cellular models of neuropsychiatric disorders. The knowledge derived from these studies may provide the neurobiological basis for rational development of A2A receptor agents as treatment strategies for neuropsychological disorders, ranging from Parkinson’s disease to drug addiction. Akihisa Mori, Ph.D., is a global expert for Adenosine receptor neuroscience as well as Parkinson’s disease, having more than 3 decades experience to work for pharmaceutical industry from basic science, exploratory and translational research to global clinical development, for antiparkinsonian therapeutics. As for adenosine receptor neuroscience, he has discovered a functional significance of Adenosine A2A receptor in the basal ganglia as well as the adenosine A2A receptor antagonism mode of action as antiparkinsonian therapy. Also, he has made global leadership to develop a first-in class adenosine A2A receptor antagonist, Istradefylline, delivering the product to successful approval in the US and Japan. He has previously participated to be the Editor for volume 119 (Adenosine Receptors in Neurology and Psychiatry) of International Review of Neurobiology.
